[Catabolite repression of xylose isomerase synthesis in Arthrobacter ureafaciens].

The effect of a specific substrate as well as other carbon sources on the biosynthesis of xylose isomerase in the actinobacterium Arthrobacter ureafaciens BIM B-6 has been studied. It was established that xylose and its structural analogue xylite induced the production of the enzyme by bacterial cells. The inducing effect peaked at a concentration of specific substrates of 0.025% (as carbon) and then remained unchanged irrespective of the substrate amount. It has been shown that the synthesis of xylose isomerase by A. ureafaciens is controlled by catabolite repression occurring at the transcription level and mediated by cyclic 3',5'-AMP.