CONTEXT: Metabolic syndrome and periodontitis both have an increasing prevalence worldwide; however, limited information is available on their association. OBJECTIVE: The objective of the study was to assess the association between periodontitis and the metabolic syndrome in a cross-sectional survey of a nationally representative sample of the noninstitutionalized civilians in the United States. DESIGN, SETTING, AND PARTICIPANTS: Data analysis from the Third National Health and Nutrition Examination Survey on 13,994 men and women aged 17 yr or older who received periodontal examination were studied. MAIN OUTCOME MEASURES: Association of diagnosis and extent of periodontitis (gingival bleeding, probing pocket depths) with the metabolic syndrome and its individual component conditions (central obesity, hypertriglyceridemia, low high-density lipoprotein-cholesterol, hypertension, and insulin resistance) were measured. Adjustment for age, sex, years of education, poverty to income ratio, ethnicity, general conditions, and smoking were considered. RESULTS: The prevalence of the metabolic syndrome was 18% [95% confidence interval (CI) 16-19], 34% (95% CI 29-38), and 37% (95% CI 28-48) among individuals with no-mild, moderate, and severe periodontitis, respectively. After adjusting for confounders, participants aged older than 45 yr suffering from severe periodontitis were 2.31 times (95% CI 1.13-4.73) more likely to have the metabolic syndrome than unaffected individuals. Diagnosis of metabolic syndrome increased by 1.12 times (95% CI 1.07-1.18) per 10% increase in gingival bleeding and 1.13 times (95% CI 1.03-1.24) per 10% increase in the proportion of periodontal pockets. CONCLUSIONS: Severe periodontitis is associated with metabolic syndrome in middle-aged individuals. Further studies are required to test whether improvements in oral health lead to reductions in cardiometabolic traits and the risk of metabolic syndrome or vice versa.
CONTEXT: Metabolic syndrome and periodontitis both have an increasing prevalence worldwide; however, limited information is available on their association. OBJECTIVE: The objective of the study was to assess the association between periodontitis and the metabolic syndrome in a cross-sectional survey of a nationally representative sample of the noninstitutionalized civilians in the United States. DESIGN, SETTING, AND PARTICIPANTS: Data analysis from the Third National Health and Nutrition Examination Survey on 13,994 men and women aged 17 yr or older who received periodontal examination were studied. MAIN OUTCOME MEASURES: Association of diagnosis and extent of periodontitis (gingival bleeding, probing pocket depths) with the metabolic syndrome and its individual component conditions (central obesity, hypertriglyceridemia, low high-density lipoprotein-cholesterol, hypertension, and insulin resistance) were measured. Adjustment for age, sex, years of education, poverty to income ratio, ethnicity, general conditions, and smoking were considered. RESULTS: The prevalence of the metabolic syndrome was 18% [95% confidence interval (CI) 16-19], 34% (95% CI 29-38), and 37% (95% CI 28-48) among individuals with no-mild, moderate, and severe periodontitis, respectively. After adjusting for confounders, participants aged older than 45 yr suffering from severe periodontitis were 2.31 times (95% CI 1.13-4.73) more likely to have the metabolic syndrome than unaffected individuals. Diagnosis of metabolic syndrome increased by 1.12 times (95% CI 1.07-1.18) per 10% increase in gingival bleeding and 1.13 times (95% CI 1.03-1.24) per 10% increase in the proportion of periodontal pockets. CONCLUSIONS:Severe periodontitis is associated with metabolic syndrome in middle-aged individuals. Further studies are required to test whether improvements in oral health lead to reductions in cardiometabolic traits and the risk of metabolic syndrome or vice versa.
Authors: Joshua H Gordon; Michael J LaMonte; Jiwei Zhao; Robert J Genco; Thomas R Cimato; Kathleen M Hovey; Matthew A Allison; Charles P Mouton; Jean Wactawski-Wende Journal: Am J Hypertens Date: 2019-01-15 Impact factor: 2.689
Authors: Anne E Sanders; Greg K Essick; James D Beck; Jianwen Cai; Shirley Beaver; Tracy L Finlayson; Phyllis C Zee; Jose S Loredo; Alberto R Ramos; Richard H Singer; Monik C Jimenez; Janice M Barnhart; Susan Redline Journal: Sleep Date: 2015-08-01 Impact factor: 5.849
Authors: Gian Luca Sfasciotti; Roberta Marini; Andrea Pacifici; Gaetano Ierardo; Luciano Pacifici; Antonella Polimeni Journal: Ann Stomatol (Roma) Date: 2017-01-10
Authors: Sona Rivas-Tumanyan; Donna Spiegelman; Gary C Curhan; John P Forman; Kaumudi J Joshipura Journal: Am J Hypertens Date: 2012-04-05 Impact factor: 2.689