CONTEXT: Vitamin D has been shown to influence cardiac contractility and myocardial calcium homeostasis. OBJECTIVES: We aimed to elucidate whether insufficient vitamin D status is associated with heart failure and sudden cardiac death (SCD). DESIGN, SETTING, AND PARTICIPANTS: We measured 25-hydroxyvitamin D [25(OH)D] levels in 3299 Caucasian patients who were routinely referred to coronary angiography at baseline (1997-2000). MAIN OUTCOME MEASURES: The main outcome was cross-sectional associations of 25(OH)D levels with measures of heart failure and Cox proportional hazard ratios for deaths due to heart failure and for SCD according to vitamin D status. RESULTS: 25(OH)D was negatively correlated with N-terminal pro-B-type natriuretic peptide and was inversely associated with higher New York Heart Association classes and impaired left ventricular function. During a median follow-up time of 7.7 yr, 116 patients died due to heart failure and 188 due to SCD. After adjustment for cardiovascular risk factors, the hazard ratios (with 95% confidence intervals) for death due to heart failure and for SCD were 2.84 (1.20-6.74) and 5.05 (2.13-11.97), respectively, when comparing patients with severe vitamin D deficiency [25(OH)D <25 nmol/liter)] with persons in the optimal range [25(OH)D > or =75 nmol/liter]. In all statistical analyses, we obtained similar results with 25(OH)D and with 1,25-dihydroxyvitamin D. CONCLUSIONS: Low levels of 25(OH)D and 1,25-dihydroxyvitamin D are associated with prevalent myocardial dysfunction, deaths due to heart failure, and SCD. Interventional trials are warranted to elucidate whether vitamin D supplementation is useful for treatment and/or prevention of myocardial diseases.
CONTEXT: Vitamin D has been shown to influence cardiac contractility and myocardial calcium homeostasis. OBJECTIVES: We aimed to elucidate whether insufficient vitamin D status is associated with heart failure and sudden cardiac death (SCD). DESIGN, SETTING, AND PARTICIPANTS: We measured 25-hydroxyvitamin D [25(OH)D] levels in 3299 Caucasian patients who were routinely referred to coronary angiography at baseline (1997-2000). MAIN OUTCOME MEASURES: The main outcome was cross-sectional associations of 25(OH)D levels with measures of heart failure and Cox proportional hazard ratios for deaths due to heart failure and for SCD according to vitamin D status. RESULTS: 25(OH)D was negatively correlated with N-terminal pro-B-type natriuretic peptide and was inversely associated with higher New York Heart Association classes and impaired left ventricular function. During a median follow-up time of 7.7 yr, 116 patients died due to heart failure and 188 due to SCD. After adjustment for cardiovascular risk factors, the hazard ratios (with 95% confidence intervals) for death due to heart failure and for SCD were 2.84 (1.20-6.74) and 5.05 (2.13-11.97), respectively, when comparing patients with severe vitamin D deficiency [25(OH)D <25 nmol/liter)] with persons in the optimal range [25(OH)D > or =75 nmol/liter]. In all statistical analyses, we obtained similar results with 25(OH)D and with 1,25-dihydroxyvitamin D. CONCLUSIONS: Low levels of 25(OH)D and 1,25-dihydroxyvitamin D are associated with prevalent myocardial dysfunction, deaths due to heart failure, and SCD. Interventional trials are warranted to elucidate whether vitamin D supplementation is useful for treatment and/or prevention of myocardial diseases.
Authors: Rajat Deo; Ronit Katz; Michael G Shlipak; Nona Sotoodehnia; Bruce M Psaty; Mark J Sarnak; Linda F Fried; Michel Chonchol; Ian H de Boer; Daniel Enquobahrie; David Siscovick; Bryan Kestenbaum Journal: Hypertension Date: 2011-11-07 Impact factor: 10.190
Authors: Marcella D Walker; Elaine Cong; Anna Kepley; Marco R Di Tullio; Tatjana Rundek; Shunichi Homma; James A Lee; Rui Liu; Polly Young; Chiyuan Zhang; Donald J McMahon; Shonni J Silverberg Journal: J Clin Endocrinol Metab Date: 2013-11-27 Impact factor: 5.958
Authors: A J van Ballegooijen; M Visser; M F Cotch; A E Arai; M Garcia; T B Harris; L J Launer; G Eiríksdóttir; V Gudnason; I A Brouwer Journal: J Clin Endocrinol Metab Date: 2013-04-12 Impact factor: 5.958
Authors: Daniela Veit Barreto; Fellype Carvalho Barreto; Sophie Liabeuf; Mohammed Temmar; Francis Boitte; Gabriel Choukroun; Albert Fournier; Ziad A Massy Journal: Clin J Am Soc Nephrol Date: 2009-05-14 Impact factor: 8.237
Authors: P Ameri; M Canepa; Y Milaneschi; P Spallarossa; G Leoncini; F Giallauria; J B Strait; E G Lakatta; C Brunelli; G Murialdo; L Ferrucci Journal: J Intern Med Date: 2012-11-12 Impact factor: 8.989