| Literature DB >> 1868027 |
J M Buesa1, H T Mouridsen, A T van Oosterom, J Verweij, T Wagener, W Steward, A Poveda, P M Vestlev, D Thomas, R Sylvester.
Abstract
Forty-four of 50 adult patients with advanced soft-tissue sarcoma who had received previous chemotherapy were evaluable for response after treatment with DTIC. The therapeutic schedule consisted of DTIC 1.2 g/m2 infused over 20 minutes, and repeated every 3 weeks. There were 1 complete and 7 partial remissions (objective activity 18%, 95% C.I. 7%-29%), with a median duration of 8 weeks (range 5-19), with the complete remission lasting 1 yr. Hematologic toxicity was dose-limiting; W.H.O. greater than or equal to 3 values were observed for WBC in 36%, and for platelets in 26% of patients. The non-hematologic toxicity included nausea and vomiting (90%), a flu-like syndrome (49%), diarrhea (35%), pain in the infused vein (28%) and hypotensive episodes (4%). Intermittent high-dose DTIC is active in advanced soft-tissue sarcoma and should be considered for inclusion in combination regimens.Entities:
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Year: 1991 PMID： 1868027 DOI： 10.1093/oxfordjournals.annonc.a057942
Source DB: PubMed Journal: Ann Oncol ISSN： 0923-7534 Impact factor: 32.976