Literature DB >> 18679616

Methods for the production of helper-dependent adenoviral vectors.

Donna J Palmer1, Philip Ng.   

Abstract

Helper-dependent adenoviral vectors (HDAd) are deleted of all viral coding sequences and have demonstrated tremendous potential for gene therapy by providing long-term, high-level transgene expression in the absence of chronic toxicity. Thus, HDAd are superior to early generation Ad for gene therapy of genetic diseases where long-term transgene expression is required. This chapter describes in detail the rescue, amplification, and large-scale production of HDAd.

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Year:  2008        PMID： 18679616     DOI： 10.1007/978-1-59745-237-3_3

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  26 in total

1.  Large-scale production of high-quality helper-dependent adenoviral vectors using adherent cells in cell factories.

Authors:  Masataka Suzuki; Racel Cela; Christian Clarke; Terry K Bertin; Susana Mouriño; Brendan Lee
Journal:  Hum Gene Ther       Date:  2010-01       Impact factor: 5.695

2.  Preclinical Efficacy and Safety Profile of Allometrically Scaled Doses of Doxycycline Used to Turn "On" Therapeutic Transgene Expression from High-Capacity Adenoviral Vectors in a Glioma Model.

Authors:  Nathan VanderVeen; Nicholas Raja; Elizabeth Yi; Henry Appelman; Philip Ng; Donna Palmer; Daniel Zamler; Marta Dzaman; Pedro R Lowenstein; Maria G Castro
Journal:  Hum Gene Ther Methods       Date:  2016-04-28       Impact factor: 2.396

3.  Linearized oncolytic adenoviral plasmid DNA delivered by bioreducible polymers.

Authors:  Jaesung Kim; Pyung-Hwan Kim; Hye Yeong Nam; Jung-Sun Lee; Chae-Ok Yun; Sung Wan Kim
Journal:  J Control Release       Date:  2011-12-20       Impact factor: 9.776

4.  Conditional disruption of hepatic carbamoyl phosphate synthetase 1 in mice results in hyperammonemia without orotic aciduria and can be corrected by liver-directed gene therapy.

Authors:  Suhail Khoja; Matt Nitzahn; Kip Hermann; Brian Truong; Roberta Borzone; Brandon Willis; Mitchell Rudd; Donna J Palmer; Philip Ng; Nicola Brunetti-Pierri; Gerald S Lipshutz
Journal:  Mol Genet Metab       Date:  2018-04-12       Impact factor: 4.797

5.  Pancreatic transduction by helper-dependent adenoviral vectors via intraductal delivery.

Authors:  Meritxell Morró; Joan Teichenne; Veronica Jimenez; Ramona Kratzer; Serena Marletta; Luca Maggioni; Cristina Mallol; Jesus Ruberte; Stefan Kochanek; Fatima Bosch; Eduard Ayuso
Journal:  Hum Gene Ther       Date:  2014-09       Impact factor: 5.695

6.  A novel bicistronic high-capacity gutless adenovirus vector that drives constitutive expression of herpes simplex virus type 1 thymidine kinase and tet-inducible expression of Flt3L for glioma therapeutics.

Authors:  Mariana Puntel; A K M G Muhammad; Marianela Candolfi; Alireza Salem; Kader Yagiz; Catherine Farrokhi; Kurt M Kroeger; Weidong Xiong; James F Curtin; Chunyan Liu; Niyati S Bondale; Jonathan Lerner; Robert N Pechnick; Donna Palmer; Philip Ng; Pedro R Lowenstein; Maria G Castro
Journal:  J Virol       Date:  2010-04-07       Impact factor: 5.103

7.  Adenovirus-retrovirus hybrid vectors achieve highly enhanced tumor transduction and antitumor efficacy in vivo.

Authors:  Shuji Kubo; Kazunori Haga; Atsuko Tamamoto; Donna J Palmer; Philip Ng; Haruki Okamura; Noriyuki Kasahara
Journal:  Mol Ther       Date:  2010-08-31       Impact factor: 11.454

8.  Modifications of adenovirus hexon allow for either hepatocyte detargeting or targeting with potential evasion from Kupffer cells.

Authors:  Jan-Michael Prill; Sigrid Espenlaub; Ulrike Samen; Tatjana Engler; Erika Schmidt; Francesco Vetrini; Amanda Rosewell; Nathan Grove; Donna Palmer; Philip Ng; Stefan Kochanek; Florian Kreppel
Journal:  Mol Ther       Date:  2010-10-19       Impact factor: 11.454

9.  Safety profile, efficacy, and biodistribution of a bicistronic high-capacity adenovirus vector encoding a combined immunostimulation and cytotoxic gene therapy as a prelude to a phase I clinical trial for glioblastoma.

Authors:  Mariana Puntel; Ghulam Muhammad A K M; Catherine Farrokhi; Nathan Vanderveen; Christopher Paran; Ashley Appelhans; Kurt M Kroeger; Alireza Salem; Liliana Lacayo; Robert N Pechnick; Kyle R Kelson; Sukhpreet Kaur; Sean Kennedy; Donna Palmer; Philip Ng; Chunyan Liu; Johnny Krasinkiewicz; Pedro R Lowenstein; Maria G Castro
Journal:  Toxicol Appl Pharmacol       Date:  2013-02-09       Impact factor: 4.219

10.  Helper-Dependent Adenoviral Vectors.

Authors:  Amanda Rosewell; Francesco Vetrini; Philip Ng
Journal:  J Genet Syndr Gene Ther       Date:  2011-10-29
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