| Literature DB >> 18678488 |
Marine Desage-El Murr1, Celine Cano, Bernard T Golding, Ian R Hardcastle, Marc Hummersome, Mark Frigerio, Nicola J Curtin, Keith Menear, Caroline Richardson, Graeme C M Smith, Roger J Griffin.
Abstract
The synthesis and biological evaluation of libraries of 8-biarylchromen-4-ones enabled the elucidation of structure-activity relationships for inhibition of the DNA-dependent protein kinase (DNA-PK), with 8-(3-(thiophen-2-yl)phenyl)chromen-4-one and 8-(3-(thiophen-3-yl)phenyl)chromen-4-one being especially potent inhibitors.Entities:
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Year: 2008 PMID： 18678488 DOI： 10.1016/j.bmcl.2008.07.066
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823