Literature DB >> 18678484

A novel 5-[1,3,4-oxadiazol-2-yl]-N-aryl-4,6-pyrimidine diamine having dual EGFR/HER2 kinase activity: design, synthesis, and biological activity.

Terry V Hughes1, Guozhang Xu, Steven K Wetter, Peter J Connolly, Stuart L Emanuel, Prabha Karnachi, Scott R Pollack, Niranjan Pandey, Mary Adams, Sandra Moreno-Mazza, Steven A Middleton, Lee M Greenberger.   

Abstract

A novel 5-[1,3,4-oxadiazol-2-yl]-N-aryl-4,6-pyrimidine diamine was synthesized and found to have potent dual EGFR/HER2 kinase inhibitory activity. The structure-based drug design of this molecule as well as the kinase and cellular inhibition of HER2 kinase dependent cell lines will be discussed.

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Year:  2008        PMID： 18678484     DOI： 10.1016/j.bmcl.2008.07.057

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

1.  Identifying HER2 inhibitors from natural products database.

Authors:  Shun-Chieh Yang; Su-Sen Chang; Calvin Yu-Chian Chen
Journal:  PLoS One       Date:  2011-12-12       Impact factor: 3.240

2.  Synthesis, Anticancer Activity and Molecular Docking Studies of Novel N-Mannich Bases of 1,3,4-Oxadiazole Based on 4,6-Dimethylpyridine Scaffold.

Authors:  Małgorzata Strzelecka; Teresa Glomb; Małgorzata Drąg-Zalesińska; Julita Kulbacka; Anna Szewczyk; Jolanta Saczko; Paulina Kasperkiewicz-Wasilewska; Nina Rembiałkowska; Kamil Wojtkowiak; Aneta Jezierska; Piotr Świątek
Journal:  Int J Mol Sci       Date:  2022-09-22       Impact factor: 6.208

3.  Synthesis and evaluation of antiinflammatory, analgesic and ulcerogenic potential of NSAIDs bearing 1,3,4-oxadiazole scaffold.

Authors:  R R Somani; U V Bhanushali
Journal:  Indian J Pharm Sci       Date:  2011-11       Impact factor: 0.975
  3 in total

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