Literature DB >> 18676884

Macrolide antibiotic-mediated downregulation of MexAB-OprM efflux pump expression in Pseudomonas aeruginosa.

Makoto Sugimura1, Hideaki Maseda, Hideaki Hanaki, Taiji Nakae.   

Abstract

Macrolide antibiotics modulate the quorum-sensing system of Pseudomonas aeruginosa. We tested the effect of macrolide antibiotics on the cell density-dependent expression of the MexAB-OprM efflux pump and found that 1.0 mug/ml (MIC/6.25) of azithromycin suppressed the expression of MexAB-OprM by about 70%, with the result that the cells became two- to fourfold more susceptible to antibiotics such as aztreonam, tetracycline, carbenicillin, chloramphenicol, and novobiocin.

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Year:  2008        PMID： 18676884      PMCID： PMC2573159          DOI： 10.1128/AAC.00511-08

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  30 in total

1.  Membrane topology of the xenobiotic-exporting subunit, MexB, of the MexA,B-OprM extrusion pump in Pseudomonas aeruginosa.

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Journal:  J Biol Chem       Date:  1999-04-09       Impact factor: 5.157

2.  Long-term azithromycin may improve lung function in children with cystic fibrosis.

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Journal:  Lancet       Date:  1998-02-07       Impact factor: 79.321

Review 3.  Macrolides for the treatment of Pseudomonas aeruginosa infections?

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Journal:  J Antimicrob Chemother       Date:  1997-08       Impact factor: 5.790

4.  [Clinical effects of low-dose long-term erythromycin chemotherapy on diffuse panbronchiolitis].

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Journal:  Nihon Kyobu Shikkan Gakkai Zasshi       Date:  1987-06

5.  Two plasmids, X1918 and Z1918, for easy recovery of the xylE and lacZ reporter genes.

Authors:  H P Schweizer
Journal:  Gene       Date:  1993-11-30       Impact factor: 3.688

Review 6.  A family of extracytoplasmic proteins that allow transport of large molecules across the outer membranes of gram-negative bacteria.

Authors:  T Dinh; I T Paulsen; M H Saier
Journal:  J Bacteriol       Date:  1994-07       Impact factor: 3.490

7.  The role of mex-gene products in antibiotic extrusion in Pseudomonas aeruginosa.

Authors:  H Yoneyama; A Ocaktan; M Tsuda; T Nakae
Journal:  Biochem Biophys Res Commun       Date:  1997-04-28       Impact factor: 3.575

8.  'Subinhibitory' erythromycin represses production of Pseudomonas aeruginosa lectins, autoinducer and virulence factors.

Authors:  D Sofer; N Gilboa-Garber; A Belz; N C Garber
Journal:  Chemotherapy       Date:  1999 Sep-Oct       Impact factor: 2.544

9.  nalB-type mutations causing the overexpression of the MexAB-OprM efflux pump are located in the mexR gene of the Pseudomonas aeruginosa chromosome.

Authors:  K Saito; H Yoneyama; T Nakae
Journal:  FEMS Microbiol Lett       Date:  1999-10-01       Impact factor: 2.742

10.  Active efflux and diffusion are involved in transport of Pseudomonas aeruginosa cell-to-cell signals.

Authors:  J P Pearson; C Van Delden; B H Iglewski
Journal:  J Bacteriol       Date:  1999-02       Impact factor: 3.490
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  9 in total

Review 1.  Efflux-mediated drug resistance in bacteria: an update.

Authors:  Xian-Zhi Li; Hiroshi Nikaido
Journal:  Drugs       Date:  2009-08-20       Impact factor: 9.546

Review 2.  Azithromycin use in patients with cystic fibrosis.

Authors:  N Principi; F Blasi; S Esposito
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2015-02-17       Impact factor: 3.267

3.  Impact of azithromycin on the clinical and antimicrobial effectiveness of tobramycin in the treatment of cystic fibrosis.

Authors:  Dave P Nichols; Carrie L Happoldt; Preston E Bratcher; Silvia M Caceres; James F Chmiel; Kenneth C Malcolm; Milene T Saavedra; Lisa Saiman; Jennifer L Taylor-Cousar; Jerry A Nick
Journal:  J Cyst Fibros       Date:  2016-12-24       Impact factor: 5.482

4.  Efflux pump inhibitors (EPIs) as new antimicrobial agents against Pseudomonas aeruginosa.

Authors:  Momen Askoura; Walid Mottawea; Turki Abujamel; Ibrahim Taher
Journal:  Libyan J Med       Date:  2011-05-13       Impact factor: 1.657

5.  Impact of ureido/carboxypenicillin resistance on the prognosis of ventilator-associated pneumonia due to Pseudomonas aeruginosa.

Authors:  Catherine Kaminski; Jean-François Timsit; Yohann Dubois; Jean-Ralph Zahar; Maïté Garrouste-Orgeas; Aurélien Vesin; Elie Azoulay; Céline Feger; Anne-Sylvie Dumenil; Christophe Adrie; Yves Cohen; Bernard Allaouchiche
Journal:  Crit Care       Date:  2011-04-11       Impact factor: 9.097

Review 6.  Responses of Pseudomonas aeruginosa to antimicrobials.

Authors:  Yuji Morita; Junko Tomida; Yoshiaki Kawamura
Journal:  Front Microbiol       Date:  2014-01-08       Impact factor: 5.640

Review 7.  Antivirulence activity of azithromycin in Pseudomonas aeruginosa.

Authors:  Francesco Imperi; Livia Leoni; Paolo Visca
Journal:  Front Microbiol       Date:  2014-04-22       Impact factor: 5.640

8.  Sodium houttuyfonate affects production of N-acyl homoserine lactone and quorum sensing-regulated genes expression in Pseudomonas aeruginosa.

Authors:  Daqiang Wu; Weifeng Huang; Qiangjun Duan; Fang Li; Huijuan Cheng
Journal:  Front Microbiol       Date:  2014-11-26       Impact factor: 5.640

9.  Aminoglycoside-inducible expression of the mexAB-oprM multidrug efflux operon in Pseudomonas aeruginosa: Involvement of the envelope stress-responsive AmgRS two-component system.

Authors:  Michael Fruci; Keith Poole
Journal:  PLoS One       Date:  2018-10-05       Impact factor: 3.240
  9 in total

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