Literature DB >> 1867652

Comparison of the chromatographic characteristics of metabolites of tacrine hydrochloride in human serum and urine with those of in vitro metabolic products from hepatic microsomes.

C A Truman1, J M Ford, C J Roberts.   

Abstract

There may be as many as five metabolites of THA in man, four corresponding to products in the rat. The study provides some evidence that one of major metabolites is 1-hydroxy-THA but lends no support to the putative oxidative deamination pathway.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 1867652     DOI： 10.1016/0006-2952(91)90061-9

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  5 in total

1.  Distribution of tacrine across the blood-brain barrier in awake, freely moving rats using in vivo microdialysis sampling.

Authors:  M Telting-Diaz; C E Lunte
Journal:  Pharm Res       Date:  1993-01       Impact factor: 4.200

2.  Characteristics of plasma protein binding of tacrine hydrochloride: a new drug for Alzheimer's disease.

Authors:  P M Mäkelä; C A Truman; J M Ford; C J Roberts
Journal:  Eur J Clin Pharmacol       Date:  1994       Impact factor: 2.953

3.  Caffeine based measures of CYP1A2 activity correlate with oral clearance of tacrine in patients with Alzheimer's disease.

Authors:  R J Fontana; T M deVries; T F Woolf; M J Knapp; A S Brown; L S Kaminsky; B K Tang; N L Foster; R R Brown; P B Watkins
Journal:  Br J Clin Pharmacol       Date:  1998-09       Impact factor: 4.335

Review 4.  Clinical pharmacokinetics of tacrine.

Authors:  S Madden; V Spaldin; B K Park
Journal:  Clin Pharmacokinet       Date:  1995-06       Impact factor: 6.447

Review 5.  Tacrine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in Alzheimer's disease.

Authors:  A J Wagstaff; D McTavish
Journal:  Drugs Aging       Date:  1994-06       Impact factor: 3.923
  5 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.