| Literature DB >> 18676149 |
Yohei Takahashi1, Takaaki Kubota, Junji Ito, Yuzuru Mikami, Jane Fromont, Jun'ichi Kobayashi.
Abstract
Three new sesquiterpenoid quinones, nakijiquinones G-I (1-3), containing a different amino group derived from amino acids have been isolated from Okinawan marine sponges of the family Spongiidae, and the structures and relative stereochemistry of 1-3 were elucidated on the basis of the spectral data. Nakijiquinones G-I (1-3) showed modest cytotoxicity and inhibitory activity against HER2 kinase, while nakijiquinone H (2) exhibited antimicrobial activity.Entities:
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Year: 2008 PMID： 18676149 DOI： 10.1016/j.bmc.2008.07.028
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641