| Literature DB >> 18675922 |
Li Liu1, Shuang Wang, Qingling Zhang, Yanqing Ding.
Abstract
Tiam1 (T-cell lymphoma invasion and metastasis-inducing protein 1), a guanine nucleotide exchange factor that activates Rac, is a colorectal cancer metastasis-related gene. In this study, we aimed to better understand the mechanism underlying Tiam1-mediated metastasis. We applied gene microarray and proteome analysis and compared expression of genes and proteins in a stable Tiam1-silencing colorectal cancer cell line and in a control cell line. Our analysis identified three genes, high-mobility group box1 (HMGB1), annexin IV (ANXA4) and phosphoglycerate mutase 1 (PGAM1) that were associated with Tiam1. Analysis of these proteins, which may be directly or indirectly regulated by Tiam1, may provide insight into the role and mechanism of Tiam1 in colorectal cancer metastasis.Entities:
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Year: 2008 PMID： 18675922 DOI： 10.1016/j.cellbi.2008.07.004
Source DB: PubMed Journal: Cell Biol Int ISSN： 1065-6995 Impact factor: 3.612