| Literature DB >> 18675832 |
Peter W Kalivas1, Ryan T Lalumiere, Lori Knackstedt, Haowei Shen.
Abstract
Cortico-striatal glutamate transmission has been implicated in both the initiation and expression of addiction related behaviors, such as locomotor sensitization and drug-seeking. While glutamate transmission onto dopamine cells in the ventral tegmental area undergoes transient plasticity important for establishing addiction-related behaviors, glutamatergic plasticity in the nucleus accumbens is critical for the expression of these behaviors. This information points to the value of exploring pharmacotherapeutic manipulation of glutamate plasticity in treating drug addiction.Entities:
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Year: 2008 PMID: 18675832 PMCID: PMC3280337 DOI: 10.1016/j.neuropharm.2008.07.011
Source DB: PubMed Journal: Neuropharmacology ISSN: 0028-3908 Impact factor: 5.250