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Literature DB >> 186756

Negative inotropic effect of cyclic GMP in cardiac fiber fragments.

Abstract

The force of spontaneously beating cardiac cellular fragments obtained from mice heart by homogenization was recorded in presence of cyclic guanosine -3'.5'-monophosphate (cGMP) and cyclic 8-bromguanosine -3'.5'-monophosphate in concentrations of 3 X 10(-6) M - 33 X 10(-6) M. The nucleotide decreased the force and reduced the rate of spontaneity. Eventually the preparation became quiescent. It is thought that this nucleotide either reduces the capacity to sequester calcium or affects its release from the sarcotubular system.

Entities: Chemical Gene Species

Mesh：

Substances：
Cyclic GMP

Year: 1976 PMID： 186756 DOI： 10.1007/bf00585895

Source DB: PubMed Journal: Pflugers Arch ISSN： 0031-6768 Impact factor: 3.657

8 in total

1. Relaxing and inotropic effects of cyclic AMP on skinned cardiac cells.

Authors: A Fabiato; F Fabiato
Journal: Nature Date: 1975-02-13 Impact factor: 49.962

2. Cyclic AMP and cyclic GMP may play opposing roles in influencing force of contraction in mammalian myocardium.

Authors: H Nawrath
Journal: Nature Date: 1976-08-05 Impact factor: 49.962

3. On the mechanism of the negative inotropic effect of acetylcholine.

Authors: R Ten Eick; H Nawrath; T F McDonald; W Trautwein
Journal: Pflugers Arch Date: 1976-02-24 Impact factor: 3.657

4. Cyclic changes in levels of cyclic AMP and cyclic GMP in frog myocardium during the cardiac cycle.

Authors: A Wollenberger; E B Babskii; E G Krause; S Genz; D Blohm; E V Bogdanova
Journal: Biochem Biophys Res Commun Date: 1973-11-16 Impact factor: 3.575

5. Cyclic AMP mediates the effects of adrenaline on cardiac purkinje fibres.

Authors: R W Tsien; W Giles; P Greengard
Journal: Nat New Biol Date: 1972-12-06

6. Cardiostimulatory effects of cyclic 3',5'-adenosine monophosphate and its acylated derivatives.

Authors: W R Kukovetz; G Pöch
Journal: Naunyn Schmiedebergs Arch Pharmakol Date: 1970

Review 7. Techniques of skinned cardiac cells and of isolated cardiac fibers with disrupted sarcolemmas with reference to the effects of catecholamines and of caffeine.

Authors: A Fabiato; F Fabiato
Journal: Recent Adv Stud Cardiac Struct Metab Date: 1976

8. Localization of beta adrenergic receptors, and effects of noradrenaline and cyclic nucleotides on action potentials, ionic currents and tension in mammalian cardiac muscle.

Authors: H Reuter
Journal: J Physiol Date: 1974-10 Impact factor: 5.182

8 in total

7. Are acetylcholine-induced increases in 42K efflux mediated by intracellular cyclic GMP in turtle cardiac pace-maker tissue?

Authors: B P Fleming; W Giles; J Lederer
Journal: J Physiol Date: 1981-05 Impact factor: 5.182

8. Nitric oxide regulates the calcium current in isolated human atrial myocytes.

Authors: M Kirstein; M Rivet-Bastide; S Hatem; A Bénardeau; J J Mercadier; R Fischmeister
Journal: J Clin Invest Date: 1995-02 Impact factor: 14.808

8 in total

Negative inotropic effect of cyclic GMP in cardiac fiber fragments.

1. Relaxing and inotropic effects of cyclic AMP on skinned cardiac cells.

2. Cyclic AMP and cyclic GMP may play opposing roles in influencing force of contraction in mammalian myocardium.

3. On the mechanism of the negative inotropic effect of acetylcholine.

4. Cyclic changes in levels of cyclic AMP and cyclic GMP in frog myocardium during the cardiac cycle.

5. Cyclic AMP mediates the effects of adrenaline on cardiac purkinje fibres.

6. Cardiostimulatory effects of cyclic 3',5'-adenosine monophosphate and its acylated derivatives.

Review 7. Techniques of skinned cardiac cells and of isolated cardiac fibers with disrupted sarcolemmas with reference to the effects of catecholamines and of caffeine.

8. Localization of beta adrenergic receptors, and effects of noradrenaline and cyclic nucleotides on action potentials, ionic currents and tension in mammalian cardiac muscle.

1. The effect of cGMP in rabbit auricle as studied by a cut-end method.

Review 2. Signal transduction by cGMP in heart.

3. Cyclic guanosine 3',5'-monophosphate regulates the calcium current in single cells from frog ventricle.

Review 4. The emerging role for type 5 phosphodiesterase inhibition in heart failure.

5. The effects of adenosine- and guanosine 3',5'-phosphoric acid benzyl esters on guinea-pig ventricular myocardium.

6. Cyclic GMP regulation of the L-type Ca(2+) channel current in human atrial myocytes.

7. Are acetylcholine-induced increases in 42K efflux mediated by intracellular cyclic GMP in turtle cardiac pace-maker tissue?

8. Nitric oxide regulates the calcium current in isolated human atrial myocytes.