Literature DB >> 18675453

Biocompatibility of silica coated NaYF(4) upconversion fluorescent nanocrystals.

Rufaihah Abdul Jalil1, Yong Zhang.   

Abstract

Here we report the synthesis of uniform silica coated hexagonal-phase NaYF(4) nanocrystals with strong NIR-to-visible upconversion fluorescence and its cytotoxicity and biodistribution in a rat model. The silica coated NaYF(4) nanocrystals were incubated with rat skeletal myoblasts and bone marrow-derived mesenchymal stem cells and cytotoxicity was assessed by using MTS and LDH assay. Healthy rats were injected intravenously with the nanocrystals so as to further investigate their biocompatibility and tissue distribution. The results from this study revealed that the silica coated NaYF(4) upconversion nanocrystals displayed good in vitro and in vivo biocompatibility, demonstrating their potential applications in both cellular and animal imaging systems.

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Year:  2008        PMID： 18675453     DOI： 10.1016/j.biomaterials.2008.07.012

Source DB:  PubMed          Journal:  Biomaterials        ISSN： 0142-9612            Impact factor:   12.479


  49 in total

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Review 7.  Upconversion nanoparticles: design, nanochemistry, and applications in theranostics.

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10.  Eu3+ doped α-sodium gadolinium fluoride luminomagnetic nanophosphor as a bimodal nanoprobe for high-contrast in vitro bioimaging and external magnetic field tracking applications.

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