Literature DB >> 18674906

A new multi-gram synthetic route to labeling precursors for the D(2/3) PET agent 18F-fallypride.

Kwangho Kim1, Nicole R Miller, Gary A Sulikowski, Craig W Lindsley.   

Abstract

This Letter describes a new multi-gram synthetic protocol for the preparation of the classic tosylate labeling precursor for the D(2/3) PET agent [(18)F]fallypride. In the course of our studies, we also discovered two novel labeling precusors, the previously undescribed mesylate and chloro congeners of fallypride.

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Year:  2008        PMID： 18674906      PMCID： PMC3177602          DOI： 10.1016/j.bmcl.2008.07.065

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  16 in total

1.  Dopamine D-2 receptors imaged by PET in Cebus apella using [18F]benzamide neuroleptic.

Authors:  J Mukherjee; K E Luh; N Yasillo; B D Perry; D Levy; C T Chen; C Ortega; R N Beck; M Cooper
Journal:  Eur J Pharmacol       Date:  1990-01-17       Impact factor: 4.432

2.  Human brain D1 and D2 dopamine receptors in schizophrenia, Alzheimer's, Parkinson's, and Huntington's diseases.

Authors:  P Seeman; N H Bzowej; H C Guan; C Bergeron; G P Reynolds; E D Bird; P Riederer; K Jellinger; W W Tourtellotte
Journal:  Neuropsychopharmacology       Date:  1987-12       Impact factor: 7.853

3.  Fluorinated benzamide neuroleptics--2. Synthesis and radiosynthesis of (S)-N-[(1-ethyl-2-pyrrolidinyl)methyl]-5-(3-[18F]fluoropropyl)-3- substituted-2-methoxybenzamides.

Authors:  J Mukherjee
Journal:  Int J Rad Appl Instrum A       Date:  1991

Review 4.  Two dopamine receptors: biochemistry, physiology and pharmacology.

Authors:  J C Stoof; J W Kebabian
Journal:  Life Sci       Date:  1984-12-03       Impact factor: 5.037

5.  In vitro affinities of various halogenated benzamide derivatives as potential radioligands for non-invasive quantification of D(2)-like dopamine receptors.

Authors:  Daniela Stark; Markus Piel; Harald Hübner; Peter Gmeiner; Gerhard Gründer; Frank Rösch
Journal:  Bioorg Med Chem       Date:  2007-08-19       Impact factor: 3.641

6.  Synthesis and evaluation of high affinity, aryl-substituted [18F]fluoropropylbenzamides for dopamine D-2 receptor studies.

Authors:  C A Mathis; J E Bishop; J M Gerdes; J M Whitney; K M Brennan; W J Jagust
Journal:  Int J Rad Appl Instrum B       Date:  1992-07

7.  Quantification of D2-like dopamine receptors in the human brain with 18F-desmethoxyfallypride.

Authors:  Gerhard Gründer; Thomas Siessmeier; Markus Piel; Ingo Vernaleken; Hans-Georg Buchholz; Yun Zhou; Christoph Hiemke; Dean F Wong; Frank Rösch; Peter Bartenstein
Journal:  J Nucl Med       Date:  2003-01       Impact factor: 10.057

8.  Learning networks in health and Parkinson's disease: reproducibility and treatment effects.

Authors:  Maren Carbon; Maria Felice Ghilardi; Andrew Feigin; Masafumi Fukuda; Giulia Silvestri; Marc J Mentis; Claude Ghez; James R Moeller; David Eidelberg
Journal:  Hum Brain Mapp       Date:  2003-07       Impact factor: 5.038

9.  11C-Fallypride: radiosynthesis and preliminary evaluation of a novel dopamine D2/D3 receptor PET radiotracer in non-human primate brain.

Authors:  Jogeshwar Mukherjee; Bingzhi Shi; Bradley T Christian; Sankha Chattopadhyay; Tanjore K Narayanan
Journal:  Bioorg Med Chem       Date:  2004-01-02       Impact factor: 3.641

10.  Fluorinated benzamide neuroleptics--III. Development of (S)-N-[(1-allyl-2-pyrrolidinyl)methyl]-5-(3-[18F]fluoropropyl)-2, 3-dimethoxybenzamide as an improved dopamine D-2 receptor tracer.

Authors:  J Mukherjee; Z Y Yang; M K Das; T Brown
Journal:  Nucl Med Biol       Date:  1995-04       Impact factor: 2.408
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