BACKGROUND: Cardiac computed tomography (CCT) has the potential to assess both coronary anatomy and ventricular function in a single study. We examined the agreement between CCT and myocardial perfusion scintigraphy (MPS) for the assessment of global and regional ventricular function. METHODS AND RESULTS: Research CCT was performed in 52 patients with a low to intermediate likelihood of coronary artery disease referred for MPS. Left ventricular end-diastolic volume, left ventricular end-systolic volume, left ventricular ejection fraction (LVEF), and myocardial wall motion and thickening were compared between techniques. In addition, myocardial contrast attenuation on CCT was compared with radiotracer uptake on MPS. LVEF values agreed well (mean difference, 4.1%; SD, 15.13%), but CCT left ventricular end-diastolic volume was greater compared with MPS (mean difference, 46.0 mL; SD, 33.34 mL) (P < .001). There was moderate agreement for segmental myocardial motion and thickening, with kappa values of 0.57 (95% confidence interval, 0.51-0.63) and 0.47 (95% confidence interval, 0.41-0.53), respectively. Seventeen patients had hypoattenuation in at least 1 myocardial segment on CCT. Three of four patients with concomitant abnormalities of wall motion and thickening on CCT had infarction in the same territory on MPS. CONCLUSIONS: There was good agreement for LVEF between CCT and MPS but myocardial volumes differed, and these modalities cannot be used interchangeably. Mild abnormalities of regional function are detected more commonly by CCT than by MPS. Myocardial hypoattenuation on CCT is highly specific for myocardial infarction when associated with reduction of systolic wall thickening and regional wall motion abnormality.
BACKGROUND: Cardiac computed tomography (CCT) has the potential to assess both coronary anatomy and ventricular function in a single study. We examined the agreement between CCT and myocardial perfusion scintigraphy (MPS) for the assessment of global and regional ventricular function. METHODS AND RESULTS: Research CCT was performed in 52 patients with a low to intermediate likelihood of coronary artery disease referred for MPS. Left ventricular end-diastolic volume, left ventricular end-systolic volume, left ventricular ejection fraction (LVEF), and myocardial wall motion and thickening were compared between techniques. In addition, myocardial contrast attenuation on CCT was compared with radiotracer uptake on MPS. LVEF values agreed well (mean difference, 4.1%; SD, 15.13%), but CCT left ventricular end-diastolic volume was greater compared with MPS (mean difference, 46.0 mL; SD, 33.34 mL) (P < .001). There was moderate agreement for segmental myocardial motion and thickening, with kappa values of 0.57 (95% confidence interval, 0.51-0.63) and 0.47 (95% confidence interval, 0.41-0.53), respectively. Seventeen patients had hypoattenuation in at least 1 myocardial segment on CCT. Three of four patients with concomitant abnormalities of wall motion and thickening on CCT had infarction in the same territory on MPS. CONCLUSIONS: There was good agreement for LVEF between CCT and MPS but myocardial volumes differed, and these modalities cannot be used interchangeably. Mild abnormalities of regional function are detected more commonly by CCT than by MPS. Myocardial hypoattenuation on CCT is highly specific for myocardial infarction when associated with reduction of systolic wall thickening and regional wall motion abnormality.
Authors: Manuel D Cerqueira; Neil J Weissman; Vasken Dilsizian; Alice K Jacobs; Sanjiv Kaul; Warren K Laskey; Dudley J Pennell; John A Rumberger; Thomas Ryan; Mario S Verani Journal: Circulation Date: 2002-01-29 Impact factor: 29.690
Authors: Albert C Lardo; Marco A S Cordeiro; Caterina Silva; Luciano C Amado; Richard T George; Anastasios P Saliaris; Karl H Schuleri; Veronica R Fernandes; Menekhem Zviman; Saman Nazarian; Henry R Halperin; Katherine C Wu; Joshua M Hare; Joao A C Lima Journal: Circulation Date: 2006-01-24 Impact factor: 29.690
Authors: Akhil Kapur; Katherine A Latus; Glyn Davies; Rhanju T Dhawan; Sian Eastick; Peter H Jarritt; George Roussakis; Melanie C Young; Constantinos Anagnostopoulos; Jimmy Bomanji; Durval C Costa; Dudley J Pennell; Elizabeth M Prvulovich; Peter J Ell; S Richard Underwood Journal: Eur J Nucl Med Mol Imaging Date: 2002-10-11 Impact factor: 9.236
Authors: M Emond; M B Mock; K B Davis; L D Fisher; D R Holmes; B R Chaitman; G C Kaiser; E Alderman; T Killip Journal: Circulation Date: 1994-12 Impact factor: 29.690
Authors: Edward D Nicol; James Stirrup; Eliana Reyes; Michael Roughton; Simon P G Padley; Michael B Rubens; S Richard Underwood Journal: J Nucl Cardiol Date: 2008-04-16 Impact factor: 5.952
Authors: Joshua L Busch; Adam M Alessio; James H Caldwell; Mohit Gupta; Songshou Mao; Jigar Kadakia; William Shuman; Matthew J Budoff; Kelley R Branch Journal: J Cardiovasc Comput Tomogr Date: 2011-10-24
Authors: E Maffei; G Messalli; A Palumbo; C Martini; S Seitun; A Aldrovandi; A Cuttone; E Emiliano; R Malagò; A Weustink; N Mollet; F Cademartiri Journal: Radiol Med Date: 2010-03-09 Impact factor: 3.469