Literature DB >> 18673239

The potential for targeting oncogenic WNT/beta-catenin signaling in therapy.

Kenneth B R Ewan1, Trevor C Dale.   

Abstract

There has been a surge of interest in the therapeutic targeting of the Wnt pathway following the demonstration that it is activated in a wide variety of tumors and that blocking aberrant signaling promoted tumor cell apoptosis or differentiation. This review describes recent therapeutic approaches and discusses potential opportunities for intervention at multiple levels within the Wnt pathway.

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Year:  2008        PMID： 18673239     DOI： 10.2174/138945008784911787

Source DB:  PubMed          Journal:  Curr Drug Targets        ISSN： 1389-4501            Impact factor:   3.465


  12 in total

1.  A useful approach to identify novel small-molecule inhibitors of Wnt-dependent transcription.

Authors:  Kenneth Ewan; Bozena Pajak; Mark Stubbs; Helen Todd; Olivier Barbeau; Camilo Quevedo; Hannah Botfield; Rodrigo Young; Ruth Ruddle; Lee Samuel; Alysia Battersby; Florence Raynaud; Nicholas Allen; Stephen Wilson; Branko Latinkic; Paul Workman; Edward McDonald; Julian Blagg; Wynne Aherne; Trevor Dale
Journal:  Cancer Res       Date:  2010-07-07       Impact factor: 12.701

2.  STAT3 upregulates the protein expression and transcriptional activity of β-catenin in breast cancer.

Authors:  Hanan Armanious; Pascal Gelebart; John Mackey; Yupo Ma; Raymond Lai
Journal:  Int J Clin Exp Pathol       Date:  2010-07-25

3.  Down-regulation of Sox7 is associated with aberrant activation of Wnt/b-catenin signaling in endometrial cancer.

Authors:  David W Chan; Celia S L Mak; Thomas H Y Leung; Karen K L Chan; Hextan Y S Ngan
Journal:  Oncotarget       Date:  2012-12

4.  Involvement of the Wnt/β-catenin signaling pathway in the cellular and molecular mechanisms of fibrosis in endometriosis.

Authors:  Sachiko Matsuzaki; Claude Darcha
Journal:  PLoS One       Date:  2013-10-04       Impact factor: 3.240

5.  Dysregulation of Wnt inhibitory factor 1 (Wif1) expression resulted in aberrant Wnt-β-catenin signaling and cell death of the cloaca endoderm, and anorectal malformations.

Authors:  R C-L Ng; D Matsumaru; A S-H Ho; M-M Garcia-Barceló; Z-W Yuan; D Smith; L Kodjabachian; P K-H Tam; G Yamada; V C-H Lui
Journal:  Cell Death Differ       Date:  2014-03-14       Impact factor: 15.828

6.  Protein kinase A activation enhances β-catenin transcriptional activity through nuclear localization to PML bodies.

Authors:  Mei Zhang; Emilia Mahoney; Tao Zuo; Parmeet K Manchanda; Ramana V Davuluri; Lawrence S Kirschner
Journal:  PLoS One       Date:  2014-10-09       Impact factor: 3.240

Review 7.  The opposing roles of Wnt-5a in cancer.

Authors:  S L McDonald; A Silver
Journal:  Br J Cancer       Date:  2009-07-21       Impact factor: 7.640

8.  A functional yeast survival screen of tumor-derived cDNA libraries designed to identify anti-apoptotic mammalian oncogenes.

Authors:  Moritz Eißmann; Bettina Schwamb; Inga Maria Melzer; Julia Moser; Dagmar Siele; Ulrike Köhl; Ralf Joachim Rieker; David Lukas Wachter; Abbas Agaimy; Esther Herpel; Peter Baumgarten; Michel Mittelbronn; Stefanie Rakel; Donat Kögel; Stefanie Böhm; Tony Gutschner; Sven Diederichs; Martin Zörnig
Journal:  PLoS One       Date:  2013-05-22       Impact factor: 3.240

9.  KCTD1 suppresses canonical Wnt signaling pathway by enhancing β-catenin degradation.

Authors:  Xinxin Li; Cheng Chen; Fangmei Wang; Wenhuan Huang; Zhongheng Liang; Yuzhong Xiao; Ke Wei; Zhenxing Wan; Xiang Hu; Shuanglin Xiang; Xiaofeng Ding; Jian Zhang
Journal:  PLoS One       Date:  2014-04-15       Impact factor: 3.240

10.  Discovery of potent, orally bioavailable, small-molecule inhibitors of WNT signaling from a cell-based pathway screen.

Authors:  Aurélie Mallinger; Simon Crumpler; Mark Pichowicz; Dennis Waalboer; Mark Stubbs; Olajumoke Adeniji-Popoola; Bozena Wood; Elizabeth Smith; Ching Thai; Alan T Henley; Katrin Georgi; William Court; Steve Hobbs; Gary Box; Maria-Jesus Ortiz-Ruiz; Melanie Valenti; Alexis De Haven Brandon; Robert TePoele; Birgitta Leuthner; Paul Workman; Wynne Aherne; Oliver Poeschke; Trevor Dale; Dirk Wienke; Christina Esdar; Felix Rohdich; Florence Raynaud; Paul A Clarke; Suzanne A Eccles; Frank Stieber; Kai Schiemann; Julian Blagg
Journal:  J Med Chem       Date:  2015-02-13       Impact factor: 7.446
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