Literature DB >> 18673153

Synthesis, characterization, and antimalarial activity of novel schiff-base-phenol and naphthalene-amine ligands.

Scott E Harpstrite1, Silvia D Collins, Ana Oksman, Daniel E Goldberg, Vijay Sharma.   

Abstract

Emergence of chloroquine (CQ) resistant Plasmodium falciparum strains necessitates discovery of inexpensive antimalarial drugs capable of targeting CQ-resistant strains. Towards this objective, herein we have synthesized and characterized naphthalene-Schiff bases or naphthalene-amine phenols. Among these compounds, 7 demonstrated a significant bioactivity with a half-maximal inhibitory concentration (IC(50)) of 1.7 microM against CQ-resistant Dd2 strains.

Entities:  

Mesh：

Substances：

Year:  2008        PMID： 18673153     DOI： 10.2174/157340608784872280

Source DB:  PubMed          Journal:  Med Chem        ISSN： 1573-4064            Impact factor:   2.745


  4 in total

1.  Structure-based design of novel small-molecule inhibitors of Plasmodium falciparum.

Authors:  Sandhya Kortagere; William J Welsh; Joanne M Morrisey; Thomas Daly; Ijeoma Ejigiri; Photini Sinnis; Akhil B Vaidya; Lawrence W Bergman
Journal:  J Chem Inf Model       Date:  2010-05-24       Impact factor: 4.956

2.  Antimicrobial metal-based thiophene derived compounds.

Authors:  Shakeela Yasmeen; Sajjad Hussain Sumrra; Muhammad Safwan Akram; Zahid H Chohan
Journal:  J Enzyme Inhib Med Chem       Date:  2016-10-21       Impact factor: 5.051

3.  Bio-oriented synthesis of new sulphadiazine derivatives for urease inhibition and their pharmacokinetic analysis.

Authors:  Asad Hamad; Mohsin Abbas Khan; Irshad Ahmad; Ruqaiya Khalil; Muhammad Khalid; Urva Abbas; Rahat Azhar; Jalal Uddin; Gaber El-Saber Batiha; Ajmal Khan; Zahid Shafiq; Ahmed Al-Harrasi
Journal:  Sci Rep       Date:  2021-09-23       Impact factor: 4.379

4.  Synthesis, antibacterial and antioxidant activities of Thiazole-based Schiff base derivatives: a combined experimental and computational study.

Authors:  Fitsum Lemilemu; Mamaru Bitew; Taye B Demissie; Rajalakshmanan Eswaramoorthy; Milkyas Endale
Journal:  BMC Chem       Date:  2021-12-23
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.