Literature DB >> 18673136

Nociceptin/orphanin FQ peptide receptor as a therapeutic target for obesity.

Magdalena J Przydzial1, Lora K Heisler.   

Abstract

Nociceptin/orphanin FQ (N/OFQ) peptide (NOP) receptor is a candidate target for novel therapeutics for a range of conditions, including obesity. This article reviews recent advances in understanding of N/OFQ's involvement in the regulation of food intake and appraises current developments in the rational design of antagonists aimed at the NOP receptor.

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Year:  2008        PMID： 18673136     DOI： 10.2174/138955708784912139

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  6 in total

Review 1.  Nociceptin Opioid Receptor (NOP) as a Therapeutic Target: Progress in Translation from Preclinical Research to Clinical Utility.

Authors:  Nurulain T Zaveri
Journal:  J Med Chem       Date:  2016-03-14       Impact factor: 7.446

2.  Central nociceptin/orphanin FQ system elevates food consumption by both increasing energy intake and reducing aversive responsiveness.

Authors:  Pawel K Olszewski; Martha K Grace; Shahrzad Shirazi Fard; Madeleine Le Grevès; Anica Klockars; Maurizio Massi; Helgi B Schiöth; Allen S Levine
Journal:  Am J Physiol Regul Integr Comp Physiol       Date:  2010-04-28       Impact factor: 3.619

Review 3.  UFP-112 a potent and long-lasting agonist selective for the Nociceptin/Orphanin FQ receptor.

Authors:  Girolamo Calo'; Anna Rizzi; Carlo Cifani; Maria Vittoria Micioni Di Bonaventura; Domenico Regoli; Maurizio Massi; Severo Salvadori; David G Lambert; Remo Guerrini
Journal:  CNS Neurosci Ther       Date:  2010-05-18       Impact factor: 5.243

4.  Nociceptin receptor antagonist SB 612111 decreases high fat diet binge eating.

Authors:  J Andrew Hardaway; Jennifer Jensen; Michelle Kim; Christopher M Mazzone; Jonathan A Sugam; Jeffrey F Diberto; Emily G Lowery-Gionta; Lara S Hwa; Kristen E Pleil; Cynthia M Bulik; Thomas L Kash
Journal:  Behav Brain Res       Date:  2016-03-29       Impact factor: 3.332

Review 5.  The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence.

Authors:  Jeffrey M Witkin; Michael A Statnick; Linda M Rorick-Kehn; John E Pintar; Michael Ansonoff; Yanyun Chen; R Craig Tucker; Roberto Ciccocioppo
Journal:  Pharmacol Ther       Date:  2013-11-01       Impact factor: 12.310

6.  Expression of the nociceptin/orphanin FQ receptor in the intestinal mucosa of IBS patients.

Authors:  Lu Li; Lei Dong; Shenhao Wang
Journal:  Exp Ther Med       Date:  2013-06-27       Impact factor: 2.447
  6 in total

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