Literature DB >> 18673123

Preclinical study of new TB drugs and drug combinations in mouse models.

Boris V Nikonenko1, Katherine A Sacksteder, Sam Hundert, Leo Einck, Carol A Nacy.   

Abstract

Tuberculosis (TB) remains one of the leading infectious killers in the world. New anti-TB drugs and more effective drug combinations are urgently needed, particularly given the increasing incidence of drug-resistant TB and HIV-TB co-infection. This review describes the available mouse models of TB and describes their utility in the evaluation of new TB drug candidates and in the evaluation of the efficacy of new TB drug combinations. Some of the most recent patents on promising TB drug-candidates are also mentioned here.

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Year:  2008        PMID： 18673123     DOI： 10.2174/157489108784746579

Source DB:  PubMed          Journal:  Recent Pat Antiinfect Drug Discov        ISSN： 1574-891X


  4 in total

1.  Fast standardized therapeutic-efficacy assay for drug discovery against tuberculosis.

Authors:  Joaquín Rullas; Juan Ignacio García; Manuela Beltrán; Pere-Joan Cardona; Neus Cáceres; José Francisco García-Bustos; Iñigo Angulo-Barturen
Journal:  Antimicrob Agents Chemother       Date:  2010-02-16       Impact factor: 5.191

2.  Inhibition of vaccinia virus replication by two small interfering RNAs targeting B1R and G7L genes and their synergistic combination with cidofovir.

Authors:  Solenne Vigne; Sophie Duraffour; Graciela Andrei; Robert Snoeck; Daniel Garin; Jean-Marc Crance
Journal:  Antimicrob Agents Chemother       Date:  2009-03-23       Impact factor: 5.191

3.  Location of intra- and extracellular M. tuberculosis populations in lungs of mice and guinea pigs during disease progression and after drug treatment.

Authors:  Donald R Hoff; Gavin J Ryan; Emily R Driver; Cornelius C Ssemakulu; Mary A De Groote; Randall J Basaraba; Anne J Lenaerts
Journal:  PLoS One       Date:  2011-03-21       Impact factor: 3.240

4.  Antimycobacterial drug discovery using Mycobacteria-infected amoebae identifies anti-infectives and new molecular targets.

Authors:  Valentin Trofimov; Sébastien Kicka; Sabrina Mucaria; Nabil Hanna; Fernando Ramon-Olayo; Laura Vela-Gonzalez Del Peral; Joël Lelièvre; Lluís Ballell; Leonardo Scapozza; Gurdyal S Besra; Jonathan A G Cox; Thierry Soldati
Journal:  Sci Rep       Date:  2018-03-02       Impact factor: 4.379
  4 in total

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