Bernadette Pretzl1, Ti-Sun Kim, Rolf Holle, Peter Eickholz. 1. Section of Periodontology, Department of Conservative Dentistry, Clinic for Oral, Dental, and Maxillofacial Diseases, University Hospital Heidelberg, Heidelberg, Germany.
Abstract
BACKGROUND: A 10-year follow-up study was conducted to clinically evaluate the long-term results after guided tissue regeneration (GTR) therapy of infrabony defects using non-resorbable and bioabsorbable barriers. METHODS: Twelve pairs of contralateral infrabony defects were treated in 12 subjects with advanced periodontitis. Within each subject, one defect received a non-resorbable barrier and the other received a bioabsorbable barrier by random assignment. Clinical parameters were obtained at baseline and at 12 and 120+/-6 months after surgery. RESULTS: Eight of 12 subjects were available for the examination at 120+/-6 months. Twelve and 120+/-6 months after GTR therapy statistically significant (P<0.05) vertical clinical attachment level (CAL-V) gain was observed in both groups (3.4+/-1.0 mm and 1.5+/-1.2 mm for the control group at 12 and 120 months, respectively, and 3.3+/-1.6 mm and 3.5+/-2.5 mm for the test group at 12 and 120 months, respectively). However, 120+/-6 months after GTR therapy, three infrabony defects (two controls and one test) had lost >2 mm of the attachment that had been gained 12 months after GTR therapy, and a statistically significant mean CAL-V loss of 1.7+/-1.3 mm was observed from 12 to 120+/-6 months in the control group. One tooth in the control group was lost between 60 and 120+/-6 months. The case series failed to show statistically significant differences between test and control regarding CAL-V gain 120+/-6 months after surgery. CONCLUSION: CAL-V gain achieved 12 months after GTR therapy in infrabony defects using non-resorbable and bioabsorbable barriers was stable after 10 years in 12 of 16 defects.
RCT Entities:
BACKGROUND: A 10-year follow-up study was conducted to clinically evaluate the long-term results after guided tissue regeneration (GTR) therapy of infrabony defects using non-resorbable and bioabsorbable barriers. METHODS: Twelve pairs of contralateral infrabony defects were treated in 12 subjects with advanced periodontitis. Within each subject, one defect received a non-resorbable barrier and the other received a bioabsorbable barrier by random assignment. Clinical parameters were obtained at baseline and at 12 and 120+/-6 months after surgery. RESULTS: Eight of 12 subjects were available for the examination at 120+/-6 months. Twelve and 120+/-6 months after GTR therapy statistically significant (P<0.05) vertical clinical attachment level (CAL-V) gain was observed in both groups (3.4+/-1.0 mm and 1.5+/-1.2 mm for the control group at 12 and 120 months, respectively, and 3.3+/-1.6 mm and 3.5+/-2.5 mm for the test group at 12 and 120 months, respectively). However, 120+/-6 months after GTR therapy, three infrabony defects (two controls and one test) had lost >2 mm of the attachment that had been gained 12 months after GTR therapy, and a statistically significant mean CAL-V loss of 1.7+/-1.3 mm was observed from 12 to 120+/-6 months in the control group. One tooth in the control group was lost between 60 and 120+/-6 months. The case series failed to show statistically significant differences between test and control regarding CAL-V gain 120+/-6 months after surgery. CONCLUSION: CAL-V gain achieved 12 months after GTR therapy in infrabony defects using non-resorbable and bioabsorbable barriers was stable after 10 years in 12 of 16 defects.
Authors: Hari Petsos; Ilona Koronna; Tatjana Ramich; Katrin Nickles; Bettina Dannewitz; Beate Schacher; Peter Eickholz Journal: J Clin Med Date: 2022-01-21 Impact factor: 4.241
Authors: Shahram Ghanaati; Adorján Kovács; Mike Barbeck; Jonas Lorenz; Anna Teiler; Nader Sadeghi; Charles James Kirkpatrick; Robert Sader Journal: J Cell Commun Signal Date: 2015-12-09 Impact factor: 5.782