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Literature DB >> 186722

Binding of botulinum neurotoxin to the synaptosome fraction of rat brain.

Abstract

The radioactive 125I-labelled neurotoxin of C. botulinum type A, when incubated with rat brain homogenate, is bound selectively to the synaptosome fraction. Intact toxin was liberated from the synaptosome fraction by treatment with Triton X-100, SDS, trypsin or neuraminidase.

Entities: Chemical Gene Species

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Year: 1976 PMID： 186722 DOI： 10.1007/bf00499451

Source DB: PubMed Journal: Naunyn Schmiedebergs Arch Pharmacol ISSN： 0028-1298 Impact factor: 3.000

15 in total

1. BOTULINUM TOXIN, TYPE A: EFFECTS ON CENTRAL NERVOUS SYSTEM.

Authors: E H POLLEY; J A VICK; H P CIUCHTA; D A FISCHETTI; F J MACCHITELLI; N MONTANARELLI
Journal: Science Date: 1965-02-26 Impact factor: 47.728

2. The isolation and characterization of acetylcholine-containing particles from brain.

Authors: V P WHITTAKER
Journal: Biochem J Date: 1959-08 Impact factor: 3.857

3. Localization of radioactive I25I-labelled botulinus toxin at the neuromuscular junction of mouse diaphragm.

Authors: N Hirokawa; M Kitamura
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1975 Impact factor: 3.000

4. The action of botulinum toxin on the neuro-muscular junction.

Authors: A S V BURGEN; F DICKENS; L J ZATMAN
Journal: J Physiol Date: 1949-08 Impact factor: 5.182

5. Highly purified synaptosomal membranes from rat brain. Preparation and characterization.

Authors: I B Levitan; W E Mushynski; G Ramirez
Journal: J Biol Chem Date: 1972-09-10 Impact factor: 5.157

6. An ultrastructural and chemical analysis of the effect of triton X-100 on synaptic plasma membranes.

Authors: C W Cotman; G Banker; W Levy; D Taylor
Journal: Biochim Biophys Acta Date: 1971-12-03

7. Significance of 12S toxin of Clostridium botulinum type E.

Authors: M Kitamura; S Sakaguchi; G Sakaguchi
Journal: J Bacteriol Date: 1969-06 Impact factor: 3.490

8. Chromatographic fractionation of the crystalline toxin of Clostridium botulinum type A.

Authors: B R Dasgupta; D A Boroff; E Rothstein
Journal: Biochem Biophys Res Commun Date: 1966-03-22 Impact factor: 3.575

9. Direct evidence for the specific fixation of Cl. botulinum A neurotoxin to brain matter.

Authors: E Habermann; I Heller
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1975 Impact factor: 3.000

10. Isolation and structural studies on synaptic complexes from rat brain.

Authors: C W Cotman; D Taylor
Journal: J Cell Biol Date: 1972-12 Impact factor: 10.539

7 in total

1. The action of botulinum A neurotoxin on the inhibition by antidromic stimulation of the lumbar monosynaptic reflex.

Authors: H Wiegand; H H Wellhöner
Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 1977-07 Impact factor: 3.000

2. Inhibition of botulinum neurotoxin a toxic action in vivo by synthetic synaptosome- and blocking antibody-binding regions.

Authors: M Zouhair Atassi; Behzod Z Dolimbek; Lance E Steward; K Roger Aoki
Journal: Protein J Date: 2010-07 Impact factor: 2.371

Review 3. Clostridium botulinum neurotoxin.

Authors: H Sugiyama
Journal: Microbiol Rev Date: 1980-09