Literature DB >> 18671997

ACToR--Aggregated Computational Toxicology Resource.

Richard Judson1, Ann Richard, David Dix, Keith Houck, Fathi Elloumi, Matthew Martin, Tommy Cathey, Thomas R Transue, Richard Spencer, Maritja Wolf.   

Abstract

ACToR (Aggregated Computational Toxicology Resource) is a database and set of software applications that bring into one central location many types and sources of data on environmental chemicals. Currently, the ACToR chemical database contains information on chemical structure, in vitro bioassays and in vivo toxicology assays derived from more than 150 sources including the U.S. Environmental Protection Agency (EPA), Centers for Disease Control (CDC), U.S. Food and Drug Administration (FDA), National Institutes of Health (NIH), state agencies, corresponding government agencies in Canada, Europe and Japan, universities, the World Health Organization (WHO) and non-governmental organizations (NGOs). At the EPA National Center for Computational Toxicology, ACToR helps manage large data sets being used in a high-throughput environmental chemical screening and prioritization program called ToxCast.

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Year:  2008        PMID: 18671997     DOI: 10.1016/j.taap.2007.12.037

Source DB:  PubMed          Journal:  Toxicol Appl Pharmacol        ISSN: 0041-008X            Impact factor:   4.219


  51 in total

1.  Application of pharmacokinetic modelling for 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure assessment.

Authors:  P Ruiz; L L Aylward; M Mumtaz
Journal:  SAR QSAR Environ Res       Date:  2014-11-14       Impact factor: 3.000

Review 2.  In vitro platforms for evaluating liver toxicity.

Authors:  Shyam Sundhar Bale; Lawrence Vernetti; Nina Senutovitch; Rohit Jindal; Manjunath Hegde; Albert Gough; William J McCarty; Ahmet Bakan; Abhinav Bhushan; Tong Ying Shun; Inna Golberg; Richard DeBiasio; Berk Osman Usta; D Lansing Taylor; Martin L Yarmush
Journal:  Exp Biol Med (Maywood)       Date:  2014-04-24

Review 3.  Advancing computer-aided drug discovery (CADD) by big data and data-driven machine learning modeling.

Authors:  Linlin Zhao; Heather L Ciallella; Lauren M Aleksunes; Hao Zhu
Journal:  Drug Discov Today       Date:  2020-07-11       Impact factor: 7.851

4.  High-performance metabolic profiling of plasma from seven mammalian species for simultaneous environmental chemical surveillance and bioeffect monitoring.

Authors:  Youngja H Park; Kichun Lee; Quinlyn A Soltow; Frederick H Strobel; Kenneth L Brigham; Richard E Parker; Mark E Wilson; Roy L Sutliff; Keith G Mansfield; Lynn M Wachtman; Thomas R Ziegler; Dean P Jones
Journal:  Toxicology       Date:  2012-03-01       Impact factor: 4.221

Review 5.  In vitro to in vivo extrapolation for high throughput prioritization and decision making.

Authors:  Shannon M Bell; Xiaoqing Chang; John F Wambaugh; David G Allen; Mike Bartels; Kim L R Brouwer; Warren M Casey; Neepa Choksi; Stephen S Ferguson; Grazyna Fraczkiewicz; Annie M Jarabek; Alice Ke; Annie Lumen; Scott G Lynn; Alicia Paini; Paul S Price; Caroline Ring; Ted W Simon; Nisha S Sipes; Catherine S Sprankle; Judy Strickland; John Troutman; Barbara A Wetmore; Nicole C Kleinstreuer
Journal:  Toxicol In Vitro       Date:  2017-12-05       Impact factor: 3.500

6.  New Sites for Old Suspects: Environmental Allosteric Modifiers of Nuclear Hormone Receptors.

Authors:  Bk Asare; Rv Rajnarayanan
Journal:  J Pharmacol Clin Toxicol       Date:  2015-01-17

7.  Exposure as part of a systems approach for assessing risk.

Authors:  Linda S Sheldon; Elaine A Cohen Hubal
Journal:  Environ Health Perspect       Date:  2009-04-08       Impact factor: 9.031

8.  Integrating omic technologies into aquatic ecological risk assessment and environmental monitoring: hurdles, achievements, and future outlook.

Authors:  Graham Van Aggelen; Gerald T Ankley; William S Baldwin; Daniel W Bearden; William H Benson; J Kevin Chipman; Tim W Collette; John A Craft; Nancy D Denslow; Michael R Embry; Francesco Falciani; Stephen G George; Caren C Helbing; Paul F Hoekstra; Taisen Iguchi; Yoshi Kagami; Ioanna Katsiadaki; Peter Kille; Li Liu; Peter G Lord; Terry McIntyre; Anne O'Neill; Heather Osachoff; Ed J Perkins; Eduarda M Santos; Rachel C Skirrow; Jason R Snape; Charles R Tyler; Don Versteeg; Mark R Viant; David C Volz; Tim D Williams; Lorraine Yu
Journal:  Environ Health Perspect       Date:  2010-01       Impact factor: 9.031

9.  T3DB: a comprehensively annotated database of common toxins and their targets.

Authors:  Emilia Lim; Allison Pon; Yannick Djoumbou; Craig Knox; Savita Shrivastava; An Chi Guo; Vanessa Neveu; David S Wishart
Journal:  Nucleic Acids Res       Date:  2009-11-06       Impact factor: 16.971

10.  Profiling chemicals based on chronic toxicity results from the U.S. EPA ToxRef Database.

Authors:  Matthew T Martin; Richard S Judson; David M Reif; Robert J Kavlock; David J Dix
Journal:  Environ Health Perspect       Date:  2008-10-20       Impact factor: 9.031

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