Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Integrins in lens development and disease.

Literature DB >> 18671967

Integrins in lens development and disease.

Abstract

Integrins are the major cell surface receptors for proteins in the extracellular matrix. These receptors form major cell signaling centers that are bidirectional, communicating messages between the cell and its environment. They are a large receptor family, with members well-known to regulate cellular processes essential to both development and disease. In this review we examine the literature regarding integrins in the lens. Here we cover integrin function in lens cell differentiation, in the development of the lens and in protection of the lens epithelial cell phenotype. In addition, we analyze the role of integrins in the progression of lens fibrotic diseases, focusing particularly on integrin regulation of TGFbeta signaling pathways in posterior capsule opacification (PCO) and anterior subcapsular cataract (ASC).

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Integrins

Year: 2008 PMID： 18671967 PMCID： PMC2698936 DOI： 10.1016/j.exer.2008.06.020

Source DB: PubMed Journal: Exp Eye Res ISSN： 0014-4835 Impact factor: 3.467

104 in total

1. Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines.

Authors: M E Hemler; C Crouse; A Sonnenberg
Journal: J Biol Chem Date: 1989-04-15 Impact factor: 5.157

2. Organization of collagen and other extracellular material in anterior capsular cataract.

Authors: G E Novotny; H Pau; G Arnold
Journal: Anat Anz Date: 1989

3. Distribution and function of tenascin during cranial neural crest development in the chick.

Authors: M Bronner-Fraser
Journal: J Neurosci Res Date: 1988 Oct-Dec Impact factor: 4.164

4. Macromolecular organization of bovine lens capsule.

Authors: P R Cammarata; D Cantu-Crouch; L Oakford; A Morrill
Journal: Tissue Cell Date: 1986 Impact factor: 2.466

5. Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region.

Authors: C C Ton; H Hirvonen; H Miwa; M M Weil; P Monaghan; T Jordan; V van Heyningen; N D Hastie; H Meijers-Heijboer; M Drechsler
Journal: Cell Date: 1991-12-20 Impact factor: 41.582

6. Ultrastructural investigation of extracellular structures in subcapsular white corrugated cataract (anterior capsular cataract).

Authors: H Pau; G E Novotny; G Arnold
Journal: Graefes Arch Clin Exp Ophthalmol Date: 1985 Impact factor: 3.117

7. Pathogenesis of capsular opacification after extracapsular cataract extraction. An animal model.

Authors: L M Cobo; E Ohsawa; D Chandler; R Arguello; G George
Journal: Ophthalmology Date: 1984-07 Impact factor: 12.079

8. Localisation of laminin and fibronectin during rat lens morphogenesis.

Authors: C Parmigiani; J McAvoy
Journal: Differentiation Date: 1984 Impact factor: 3.880

9. Cell type-specific integrin variants with alternative alpha chain cytoplasmic domains.

Authors: R N Tamura; H M Cooper; G Collo; V Quaranta
Journal: Proc Natl Acad Sci U S A Date: 1991-11-15 Impact factor: 11.205

10. Developmental acquisition of basement membrane heterogeneity: type IV collagen in the avian lens capsule.

Authors: J M Fitch; R Mayne; T F Linsenmayer
Journal: J Cell Biol Date: 1983-09 Impact factor: 10.539

40 in total

1. Insulin-like growth factor receptor-1 and nuclear factor κB are crucial survival signals that regulate caspase-3-mediated lens epithelial cell differentiation initiation.

Authors: Subhasree Basu; Suren Rajakaruna; A Sue Menko
Journal: J Biol Chem Date: 2012-01-24 Impact factor: 5.157

2. α6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial cell differentiation initiation.

Authors: Subhasree Basu; Suren Rajakaruna; Adèle De Arcangelis; Liping Zhang; Elisabeth Georges-Labouesse; A Sue Menko
Journal: J Biol Chem Date: 2013-12-31 Impact factor: 5.157

Integrins in lens development and disease.

1. Association of the VLA alpha 6 subunit with a novel protein. A possible alternative to the common VLA beta 1 subunit on certain cell lines.

2. Organization of collagen and other extracellular material in anterior capsular cataract.

3. Distribution and function of tenascin during cranial neural crest development in the chick.

4. Macromolecular organization of bovine lens capsule.

5. Positional cloning and characterization of a paired box- and homeobox-containing gene from the aniridia region.

6. Ultrastructural investigation of extracellular structures in subcapsular white corrugated cataract (anterior capsular cataract).

7. Pathogenesis of capsular opacification after extracapsular cataract extraction. An animal model.

8. Localisation of laminin and fibronectin during rat lens morphogenesis.

9. Cell type-specific integrin variants with alternative alpha chain cytoplasmic domains.

10. Developmental acquisition of basement membrane heterogeneity: type IV collagen in the avian lens capsule.

1. Insulin-like growth factor receptor-1 and nuclear factor κB are crucial survival signals that regulate caspase-3-mediated lens epithelial cell differentiation initiation.

2. α6 integrin transactivates insulin-like growth factor receptor-1 (IGF-1R) to regulate caspase-3-mediated lens epithelial cell differentiation initiation.

3. β1 integrin as the integrating component in cell-cell cooperation for maintenance of lens transparency.

4. Fibronectin regulates growth factor signaling and cell differentiation in primary lens cells.

5. Rac1 GTPase-deficient mouse lens exhibits defects in shape, suture formation, fiber cell migration and survival.

6. Beta-1 integrin is important for the structural maintenance and homeostasis of differentiating fiber cells.

7. Involvement of cholangiocyte proliferation in biliary fibrosis.

8. Characterizing molecular diffusion in the lens capsule.

9. Proteome-transcriptome analysis and proteome remodeling in mouse lens epithelium and fibers.

10. A cell polarity protein aPKClambda is required for eye lens formation and growth.