Literature DB >> 18669028

In vitro withanolide production by Withania somnifera L. cultures.

Farzana Sabir1, Neelam S Sangwan, Narayan D Chaurasiya, Laxmi N Misra, Rajender S Sangwan.   

Abstract

In vitro multiple shoots, root, callus and cell suspension cultures of Withania somnifera exhibited the potentiality to produce pharmacologically active withanolides. Multiple shoots cultures exhibited an increase in withanolide A accumulation compared to shoots of the mother plant. In vitro generated root cultures as well as callus and suspension cultures also produced withanolides albeit at lower levels.

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Year:  2008        PMID： 18669028     DOI： 10.1515/znc-2008-5-616

Source DB:  PubMed          Journal:  Z Naturforsch C J Biosci        ISSN： 0341-0382


  7 in total

1.  Qualitative and quantitative variations in withanolides and expression of some pathway genes during different stages of morphogenesis in Withania somnifera Dunal.

Authors:  Farzana Sabir; Smrati Mishra; Rajender S Sangwan; Jyoti S Jadaun; Neelam S Sangwan
Journal:  Protoplasma       Date:  2012-08-10       Impact factor: 3.356

2.  Withanolide biosynthesis recruits both mevalonate and DOXP pathways of isoprenogenesis in Ashwagandha Withania somnifera L. (Dunal).

Authors:  Narayan D Chaurasiya; Neelam S Sangwan; Farzana Sabir; Laxminarain Misra; Rajender S Sangwan
Journal:  Plant Cell Rep       Date:  2012-06-26       Impact factor: 4.570

3.  Cloning and homologous characterization of geranylgeranyl pyrophosphate synthase (GGPPS) from Withania somnifera revealed alterations in metabolic flux towards gibberellic acid biosynthesis.

Authors:  Yashdeep Srivastava; Sandhya Tripathi; Bhawana Mishra; Neelam S Sangwan
Journal:  Planta       Date:  2022-06-01       Impact factor: 4.116

4.  Innate endophytic fungus, Aspergillus terreus as biotic elicitor of withanolide A in root cell suspension cultures of Withania somnifera.

Authors:  Ramesh Kumar Kushwaha; Sucheta Singh; Shiv Shanker Pandey; Alok Kalra; Chikkarasanahalli Shivegowda Vivek Babu
Journal:  Mol Biol Rep       Date:  2019-01-31       Impact factor: 2.316

5.  Free radical scavenging activity and comparative metabolic profiling of in vitro cultured and field grown Withania somnifera roots.

Authors:  Kalaiselvi Senthil; Pankajavalli Thirugnanasambantham; Taek Joo Oh; So Hyun Kim; Hyung Kyoon Choi
Journal:  PLoS One       Date:  2015-04-14       Impact factor: 3.240

Review 6.  Addressing Challenges to Enhance the Bioactives of Withania somnifera through Organ, Tissue, and Cell Culture Based Approaches.

Authors:  Pritika Singh; Rupam Guleri; Amrita Angurala; Kuldeep Kaur; Kulwinder Kaur; Sunil C Kaul; Renu Wadhwa; Pratap Kumar Pati
Journal:  Biomed Res Int       Date:  2017-02-16       Impact factor: 3.411

7.  Differential Gene Expression and Withanolides Biosynthesis During in vitro and ex vitro Growth of Withania somnifera (L.) Dunal.

Authors:  Sachin Ashok Thorat; Arya Kaniyassery; Poornima Poojari; Melissa Rangel; Shashikala Tantry; Kodsara Ramachandra Kiran; Manjunath B Joshi; Padmalatha S Rai; Anna-Maria Botha; Annamalai Muthusamy
Journal:  Front Plant Sci       Date:  2022-06-14       Impact factor: 6.627
  7 in total

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