Literature DB >> 18669023

Enzymatic inhibitory activity and trypanocidal effects of extracts and compounds from Siphoneugena densiflora O. Berg and Vitex polygama Cham.

Margareth B C Gallo1, Anna Sylvia F Marques, Paulo C Vieira, Maria Fátima das G F da Silva, João B Fernandes, Márcio Silva, Rafael V Guido, Glaucius Oliva, Otávio H Thiemann, Sérgio Albuquerque, Alan H Fairlamb.   

Abstract

Hexanic, methanolic, and hydroalcoholic extracts, and 34 isolated compounds from Vitex polygama Cham. (Lamiaceae, formely Verbenaceae) and Siphoneugena densiflora O. Berg (Myrtaceae) were screened for their trypanocidal effects on bloodstream forms of Trypanosoma cruzi and T brucei, as well as for their enzymatic inhibitory activities on glycosomal glyceraldehyde-3-phosphate dehydrogenase (gGAPDH) and trypanothione reductase (TR) enzymes from T cruzi and adeninephosphoribosyl transferase (APRT) enzyme from Leishmania tarentolae. In general, polar extracts displayed strong effects and some of the tested compounds have shown good results in comparison to positive controls of the bioassays.

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Year:  2008        PMID： 18669023      PMCID： PMC3428908          DOI： 10.1515/znc-2008-5-611

Source DB:  PubMed          Journal:  Z Naturforsch C J Biosci        ISSN： 0341-0382


  19 in total

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8.  Compounds from Vitex polygama active against kidney diseases.

Authors:  Margareth B C Gallo; Paulo C Vieira; João B Fernandes; Maria Fátima das G F da Silva; Fátima R Salimena-Pires
Journal:  J Ethnopharmacol       Date:  2007-09-29       Impact factor: 4.360

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Authors:  R Takeara; S Albuquerque; N P Lopes; J L C Lopes
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Authors:  Bárbara O Henriques; Olívia Corrêa; Elaine Patrícia C Azevedo; Rodrigo M Pádua; Vívian Louise S de Oliveira; Thiago Henrique C Oliveira; Daiane Boff; Ana Carolina F Dias; Danielle G de Souza; Flávio A Amaral; Mauro M Teixeira; Rachel O Castilho; Fernão C Braga
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3.  Improved tricyclic inhibitors of trypanothione reductase by screening and chemical synthesis.

Authors:  John L Richardson; Isabelle R E Nett; Deuan C Jones; Mohamed H Abdille; Ian H Gilbert; Alan H Fairlamb
Journal:  ChemMedChem       Date:  2009-08       Impact factor: 3.466
  3 in total

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