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Literature DB >> 18668135

Rac guanosine triphosphatases represent a potential target in AML.

L U W Müller, R J Schore, Y Zheng, E K Thomas, M-O Kim, J A Cancelas, Y Gu, D A Williams.

Abstract

Entities: CellLine Chemical Disease Gene Species

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Year: 2008 PMID： 18668135 PMCID： PMC4185433 DOI： 10.1038/leu.2008.196

Source DB: PubMed Journal: Leukemia ISSN： 0887-6924 Impact factor: 11.528

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7 in total

1. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor.

Authors: Yuan Gao; J Bradley Dickerson; Fukun Guo; Jie Zheng; Yi Zheng
Journal: Proc Natl Acad Sci U S A Date: 2004-05-05 Impact factor: 11.205

2. Malignant hematopoietic cell lines: in vitro models for the study of anaplastic large-cell lymphoma.

Authors: H G Drexler; R A F MacLeod
Journal: Leukemia Date: 2004-10 Impact factor: 11.528

3. Expansion of normal and leukemic human hematopoietic stem/progenitor cells requires rac-mediated interaction with stromal cells.

Authors: Marjan Rozenveld-Geugien; Inge O Baas; Djoke van Gosliga; Edo Vellenga; Jan Jacob Schuringa
Journal: Exp Hematol Date: 2007-05 Impact factor: 3.084

4. Rac guanosine triphosphatases represent integrating molecular therapeutic targets for BCR-ABL-induced myeloproliferative disease.

Authors: Emily K Thomas; Jose A Cancelas; Hee-Don Chae; Adrienne D Cox; Patricia J Keller; Danilo Perrotti; Paolo Neviani; Brian J Druker; Kenneth D R Setchell; Yi Zheng; Chad E Harris; David A Williams
Journal: Cancer Cell Date: 2007-11 Impact factor: 31.743

Review 5. Rac GTPases as key regulators of p210-BCR-ABL-dependent leukemogenesis.

Authors: E K Thomas; J A Cancelas; Y Zheng; D A Williams
Journal: Leukemia Date: 2008-03-20 Impact factor: 11.528

6. Hematopoietic cell regulation by Rac1 and Rac2 guanosine triphosphatases.

Authors: Yi Gu; Marie-Dominique Filippi; Jose A Cancelas; Jamie E Siefring; Emily P Williams; Aparna C Jasti; Chad E Harris; Andrew W Lee; Rethinasamy Prabhakar; Simon J Atkinson; David J Kwiatkowski; David A Williams
Journal: Science Date: 2003-10-17 Impact factor: 47.728

7. Microenvironment determines lineage fate in a human model of MLL-AF9 leukemia.

Authors: Junping Wei; Mark Wunderlich; Catherine Fox; Sara Alvarez; Juan C Cigudosa; Jamie S Wilhelm; Yi Zheng; Jose A Cancelas; Yi Gu; Michael Jansen; Jorge F Dimartino; James C Mulloy
Journal: Cancer Cell Date: 2008-06 Impact factor: 31.743

7 in total

12 in total

Review 1. The diverse roles of Rac signaling in tumorigenesis.

Authors: Natalie A Mack; Helen J Whalley; Sonia Castillo-Lluva; Angeliki Malliri
Journal: Cell Cycle Date: 2011-05-15 Impact factor: 4.534

2. Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation.

Authors: Emily E Bosco; Sachin Kumar; Filippo Marchioni; Jacek Biesiada; Miroslaw Kordos; Kathleen Szczur; Jarek Meller; William Seibel; Ariel Mizrahi; Edgar Pick; Marie-Dominique Filippi; Yi Zheng
Journal: Chem Biol Date: 2012-02-24

3. Inhibition of Rac GTPase signaling and downstream prosurvival Bcl-2 proteins as combination targeted therapy in MLL-AF9 leukemia.

Authors: Benjamin Mizukawa; Junping Wei; Mahesh Shrestha; Mark Wunderlich; Fu-Sheng Chou; Andrea Griesinger; Chad E Harris; Ashish R Kumar; Yi Zheng; David A Williams; James C Mulloy
Journal: Blood Date: 2011-09-22 Impact factor: 22.113

4. Rac1 targeting suppresses p53 deficiency-mediated lymphomagenesis.

Authors: Emily E Bosco; Wenjun Ni; Lei Wang; Fukun Guo; James F Johnson; Yi Zheng
Journal: Blood Date: 2010-02-23 Impact factor: 22.113

5. Combinatorial genetics reveals the Dock1-Rac2 axis as a potential target for the treatment of NPM1;Cohesin mutated AML.

Authors: Alison E Meyer; Cary Stelloh; Kirthi Pulakanti; Robert Burns; Joseph B Fisher; Katelyn E Heimbruch; Sergey Tarima; Quinlan Furumo; John Brennan; Yongwei Zheng; Aaron D Viny; George S Vassiliou; Sridhar Rao
Journal: Leukemia Date: 2022-07-01 Impact factor: 12.883

10. ELMO1 is upregulated in AML CD34+ stem/progenitor cells, mediates chemotaxis and predicts poor prognosis in normal karyotype AML.

Authors: Marta E Capala; Edo Vellenga; Jan Jacob Schuringa
Journal: PLoS One Date: 2014-10-31 Impact factor: 3.240