Literature DB >> 18668

Trisialoganglioside synthesis by a chicken brain sialyltransferase. Comparative study with the similar reaction for the synthesis of disialoganglioside.

M G Mestrallet, F A Cumar, R Caputto.   

Abstract

An enzyme preparation from embryonic chicken brain catalyzes the transfer of sialic acid from CMP-N-acetylneuraminic acid to ceramide-Glc-Gal(NeuAc-NeuAc)-GalNAc-Gal (GDlb) to form ceramide-Glc-Gal(NeuAc-NeuAc)-GalNAc-Gal-NeuAc (GTlb). The sialyltransferase activity was measured during the development of the embryo, the subcellular distribution of this activity was determined and several kinetic properties of the reaction were examined. A comparative study with the similar reaction involved in the transfer of sialic acid to the terminal galactose in ceramide-Glc-Gal(NeuAc)-GalNAc-Gal (GMl) was made. The results obtained in this comparative study suggest that the transfer of sialic acid in both reactions is catalyzed by the same enzyme.

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Year:  1977        PMID： 18668     DOI： 10.1007/BF01732045

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  21 in total

1.  Quantitative estimation of sialic acids. II. A colorimetric resorcinol-hydrochloric acid method.

Authors:  L SVENNERHOLM
Journal:  Biochim Biophys Acta       Date:  1957-06

2.  Gangliosides of plasma membranes from normal rat liver and Morris hepatoma.

Authors:  A M Dnistrian; V P Skipski; M Barclay; E S Essner; C C Stock
Journal:  Biochem Biophys Res Commun       Date:  1975-05-05       Impact factor: 3.575

3.  An isomer of trisialoganglioside and the sturcture of tetra- and pentasialogangliosides from fish brain.

Authors:  I Ishizuka; H Wiegandt
Journal:  Biochim Biophys Acta       Date:  1972-02-21

4.  Change of glycolipid pattern in Morris hepatomas 5123 and 7800.

Authors:  B Siddiqui; S Hakomori
Journal:  Cancer Res       Date:  1970-12       Impact factor: 12.701

5.  On the pathway of biosynthesis of trisialogangliosides.

Authors:  M G Mestrallet; F A Cumar; R Caputto
Journal:  Biochem Biophys Res Commun       Date:  1974-07-10       Impact factor: 3.575

6.  Properties of some glycosyltransferases in embryonic chicken brain.

Authors:  H Den; B Kaufman; S Roseman
Journal:  J Biol Chem       Date:  1970-12-25       Impact factor: 5.157

7.  Gangliosides of hepatoma 27, normal and regenerating rat liver.

Authors:  E V Dyatlovitskaya; A M Novikov; N P Gorkova; L D Bergelson
Journal:  Eur J Biochem       Date:  1976-04-01

8.  Enzymatic synthesis of disialogangliosides from monosialogangliosides by sialyltransferases from embryonic chicken brain.

Authors:  B Kaufman; S Basu; S Roseman
Journal:  J Biol Chem       Date:  1968-11-10       Impact factor: 5.157

9.  Rat brain microsomal gangliosides. Accessibility to a neuraminidase preparation and the possible existence of different pools in relation to their biosynthesis.

Authors:  H J Maccioni; A Arce; C Landa; R Caputto
Journal:  Biochem J       Date:  1974-02       Impact factor: 3.857

10.  Enzymatic block in the synthesis of gangliosides in DNA virus-transformed tumorigenic mouse cell lines.

Authors:  F A Cumar; R O Brady; E H Kolodny; V W McFarland; P T Mora
Journal:  Proc Natl Acad Sci U S A       Date:  1970-10       Impact factor: 11.205
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  4 in total

1.  Binding of cholera toxin to pig intestinal mucosa glycosphingolipids: relationship with the ABO blood group system.

Authors:  F R Bennun; G A Roth; C G Monferran; F A Cumar
Journal:  Infect Immun       Date:  1989-03       Impact factor: 3.441

2.  Ganglioside changes in the chicken optic lobes and cerebrum during embryonic development : Transient occurrence of "novel" multisialo-gangliosides.

Authors:  Harald Rösner
Journal:  Wilehm Roux Arch Dev Biol       Date:  1980-10

3.  Surface behaviour of gangliosides and related glycosphingolipids.

Authors:  B Maggio; F A Cumar; R Caputto
Journal:  Biochem J       Date:  1978-06-01       Impact factor: 3.857

4.  Ganglioside-cholera toxin interactions: a binding and lipid monolayer study.

Authors:  F A Cumar; B Maggio; R Caputto
Journal:  Mol Cell Biochem       Date:  1982-08-06       Impact factor: 3.396
  4 in total

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