Literature DB >> 18667785

Selective and potent in vitro antitrypanosomal activities of ten microbial metabolites.

Kazuhiko Otoguro1, Aki Ishiyama, Miyuki Namatame, Aki Nishihara, Toshiaki Furusawa, Rokuro Masuma, Kazuro Shiomi, Yoko Takahashi, Haruki Yamada, Satoshi Omura.   

Abstract

More than 400 compounds isolated from soil microorganisms, and catalogued in the antibiotic library of the Kitasato Institute for Life Sciences, were screened against African trypanosomes. Ten compounds were found to have selective and potent antitrypanosomal activity in vitro: aureothin, cellocidin, destomycin A, echinomycin, hedamycin, irumamycin, LL-Z 1272beta, O-methylnanaomycin A, venturicidin A and virustomycin A. Results of the in vitro assays using the GUTat 3.1 strain of Trypanosomal brucei brucei and the STIB900 strain of T. b. rhodesiense are presented. Cytotoxicity was determined using a human MRC-5 cell line. This is the first report of antitrypanosomal activities of the 10 microbial metabolites listed above.

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Year:  2008        PMID： 18667785     DOI： 10.1038/ja.2008.52

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  6 in total

1.  In vitro antitrypanosomal activity of some phenolic compounds from propolis and lactones from Fijian Kawa (Piper methysticum).

Authors:  Kazuhiko Otoguro; Masato Iwatsuki; Aki Ishiyama; Miyuki Namatame; Aki Nishihara-Tsukashima; Hiroaki Kiyohara; Toshihiro Hashimoto; Yoshinori Asakawa; Satoshi Omura; Haruki Yamada
Journal:  J Nat Med       Date:  2011-11-25       Impact factor: 2.343

2.  In vitro antitrypanosomal activity of bis(bibenzyls)s and bibenzyls from liverworts against Trypanosoma brucei.

Authors:  Kazuhiko Otoguro; Aki Ishiyama; Masato Iwatsuki; Miyuki Namatame; Aki Nishihara-Tukashima; Hiroaki Kiyohara; Toshihiro Hashimoto; Yoshinori Asakawa; Satoshi Omura; Haruki Yamada
Journal:  J Nat Med       Date:  2011-09-16       Impact factor: 2.343

3.  Antiamoebic properties of the actinomycete metabolites echinomycin A and tirandamycin A.

Authors:  Avelina Espinosa; Aaron M Socha; Erica Ryke; David C Rowley
Journal:  Parasitol Res       Date:  2012-07-05       Impact factor: 2.289

4.  Venturicidin C, a new 20-membered macrolide produced by Streptomyces sp. TS-2-2.

Authors:  Khaled A Shaaban; Shanteri Singh; Sherif I Elshahawi; Xiachang Wang; Larissa V Ponomareva; Manjula Sunkara; Gregory C Copley; James C Hower; Andrew J Morris; Madan K Kharel; Jon S Thorson
Journal:  J Antibiot (Tokyo)       Date:  2013-11-13       Impact factor: 2.649

5.  Synthesis, characterization and in vitro antitrypanosomal activities of new carboxamides bearing quinoline moiety.

Authors:  David Izuchukwu Ugwu; Uchechukwu Chris Okoro; Narendra Kumar Mishra
Journal:  PLoS One       Date:  2018-01-11       Impact factor: 3.240

6.  In vitro screening of known drugs identified by scaffold hopping techniques shows promising leishmanicidal activity for suramin and netilmicin.

Authors:  Supriya Khanra; Y Pavan Kumar; Jyotirmayee Dash; Rahul Banerjee
Journal:  BMC Res Notes       Date:  2018-05-21
  6 in total

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