AIM: To study and determine the resting energy expenditure (REE) and oxidation rates of glucose, fat and protein in severe chronic hepatitis B patients. METHODS: A total of 100 patients with liver diseases were categorized into three groups: 16 in the acute hepatitis group, 56 in the severe chronic hepatitis group, and 28 in the cirrhosis group. The REE and the oxidation rates of glucose, fat and protein were assessed by indirect heat measurement using the CCM-D nutritive metabolic investigation system. RESULTS: The REE of the severe chronic hepatitis group (20.7 +/- 6.1 kcal/d per kg) was significantly lower than that of the acute hepatitis group (P = 0.014). The respiratory quotient (RQ) of the severe chronic hepatitis group (0.84 +/- 0.06) was significantly lower than that of the acute hepatitis and cirrhosis groups (P = 0.001). The glucose oxidation rate of the severe hepatitis group (39.2%) was significantly lower than that of the acute hepatitis group and the cirrhosis group (P < 0.05), while the fat oxidation rate (39.8%) in the severe hepatitis group was markedly higher than that of the other two groups (P < 0.05). With improvement of liver function, the glucose oxidation rate increased from 41.7% to 60.1%, while the fat oxidation rate decreased from 26.3% to 7.6%. CONCLUSION: The glucose oxidation rate is significantly decreased, and a high proportion of energy is provided by fat in severe chronic hepatitis. These results warrant a large clinical trail to assess the optimal nutritive support therapy for patients with severe liver disease.
AIM: To study and determine the resting energy expenditure (REE) and oxidation rates of glucose, fat and protein in severe chronic hepatitis B patients. METHODS: A total of 100 patients with liver diseases were categorized into three groups: 16 in the acute hepatitis group, 56 in the severe chronic hepatitis group, and 28 in the cirrhosis group. The REE and the oxidation rates of glucose, fat and protein were assessed by indirect heat measurement using the CCM-D nutritive metabolic investigation system. RESULTS: The REE of the severe chronic hepatitis group (20.7 +/- 6.1 kcal/d per kg) was significantly lower than that of the acute hepatitis group (P = 0.014). The respiratory quotient (RQ) of the severe chronic hepatitis group (0.84 +/- 0.06) was significantly lower than that of the acute hepatitis and cirrhosis groups (P = 0.001). The glucose oxidation rate of the severe hepatitis group (39.2%) was significantly lower than that of the acute hepatitis group and the cirrhosis group (P < 0.05), while the fat oxidation rate (39.8%) in the severe hepatitis group was markedly higher than that of the other two groups (P < 0.05). With improvement of liver function, the glucose oxidation rate increased from 41.7% to 60.1%, while the fat oxidation rate decreased from 26.3% to 7.6%. CONCLUSION: The glucose oxidation rate is significantly decreased, and a high proportion of energy is provided by fat in severe chronic hepatitis. These results warrant a large clinical trail to assess the optimal nutritive support therapy for patients with severe liver disease.
Authors: H Yamanaka-Okumura; T Nakamura; H Takeuchi; H Miyake; T Katayama; H Arai; Y Taketani; M Fujii; M Shimada; E Takeda Journal: Eur J Clin Nutr Date: 2006-03-01 Impact factor: 4.016
Authors: F W Guglielmi; C Panella; A Buda; G Budillon; L Caregaro; C Clerici; D Conte; A Federico; G Gasbarrini; A Guglielmi; C Loguercio; A Losco; D Martines; S Mazzuoli; M Merli; G Mingrone; A Morelli; G Nardone; G Zoli; A Francavilla Journal: Dig Liver Dis Date: 2005-09 Impact factor: 4.088
Authors: Mathias Plauth; Tatjana Schütz; Deborah P Buckendahl; Georg Kreymann; Matthias Pirlich; Sven Grüngreiff; Paul Romaniuk; Siegfried Ertl; Marie-Luise Weiss; Herbert Lochs Journal: J Hepatol Date: 2004-02 Impact factor: 25.083
Authors: Jennifer D Wallace; Winsome J Abbott-Johnson; Darrell H G Crawford; Ross Barnard; Julia M Potter; Ross C Cuneo Journal: J Clin Endocrinol Metab Date: 2002-06 Impact factor: 5.958