Literature DB >> 1866627

Proteinase-mediated cartilage degradation in osteoarthritis.

D D Dean1.   

Abstract

Osteoarthritis (OA) is a disease of complex etiology that results in articular cartilage breakdown. Current experimental evidence strongly suggests that proteinases may be involved in this loss of cartilage matrix. The present review summarizes the evidence for implicating proteinases in the etiopathogenesis of OA and suggests that blockade of proteinase activity may provide a rational basis for new therapeutic agents.

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Year:  1991        PMID： 1866627     DOI： 10.1016/0049-0172(91)90023-s

Source DB:  PubMed          Journal:  Semin Arthritis Rheum        ISSN： 0049-0172            Impact factor:   5.532


  12 in total

Review 1.  Pharmacologic therapy of osteoarthritis.

Authors:  J P Pelletier; D Choquette; B Haraoui; J P Raynauld; E Rich; J C Fernandes; J Martel-Pelletier
Journal:  Curr Rheumatol Rep       Date:  1999-10       Impact factor: 4.592

2.  The new collagenase, collagenase-3, is expressed and synthesized by human chondrocytes but not by synoviocytes. A role in osteoarthritis.

Authors:  P Reboul; J P Pelletier; G Tardif; J M Cloutier; J Martel-Pelletier
Journal:  J Clin Invest       Date:  1996-05-01       Impact factor: 14.808

3.  Nonlinear optical microscopy of early stage (ICRS Grade-I) osteoarthritic human cartilage.

Authors:  Rajesh Kumar; Kirsten M Grønhaug; Catharina L Davies; Jon O Drogset; Magnus B Lilledahl
Journal:  Biomed Opt Express       Date:  2015-04-27       Impact factor: 3.732

Review 4.  Mechanisms of joint destruction, pain and disability in osteoarthritis.

Authors:  R S Pinals
Journal:  Drugs       Date:  1996       Impact factor: 9.546

5.  Expression of 92-kD type IV collagenase/gelatinase (gelatinase B) in osteoarthritic cartilage and its induction in normal human articular cartilage by interleukin 1.

Authors:  M Mohtai; R L Smith; D J Schurman; Y Tsuji; F M Torti; N I Hutchinson; W G Stetler-Stevenson; G I Goldberg
Journal:  J Clin Invest       Date:  1993-07       Impact factor: 14.808

6.  Perturbation of adhesion molecule-mediated chondrocyte-matrix interactions by 4-hydroxynonenal binding: implication in osteoarthritis pathogenesis.

Authors:  Rana El-Bikai; Mélanie Welman; Yoran Margaron; Jean-François Côté; Luke Macqueen; Michael D Buschmann; Hassan Fahmi; Qin Shi; Karim Maghni; Julio C Fernandes; Mohamed Benderdour
Journal:  Arthritis Res Ther       Date:  2010-10-26       Impact factor: 5.156

7.  Coordinate synthesis of stromelysin, interleukin-1, and oncogene proteins in experimental osteoarthritis. An immunohistochemical study.

Authors:  J P Pelletier; M P Faure; J A DiBattista; S Wilhelm; D Visco; J Martel-Pelletier
Journal:  Am J Pathol       Date:  1993-01       Impact factor: 4.307

8.  Effects of tenoxicam and aspirin on the metabolism of proteoglycans and hyaluronan in normal and osteoarthritic human articular cartilage.

Authors:  D H Manicourt; A Druetz-Van Egeren; L Haazen; C Nagant de Deuxchaisnes
Journal:  Br J Pharmacol       Date:  1994-12       Impact factor: 8.739

9.  Secretory leukocyte protease inhibitor suppresses the inflammation and joint damage of bacterial cell wall-induced arthritis.

Authors:  X y Song; L Zeng; W Jin; J Thompson; D E Mizel; K Lei; R C Billinghurst; A R Poole; S M Wahl
Journal:  J Exp Med       Date:  1999-08-16       Impact factor: 14.307

10.  Integrin-regulated secretion of interleukin 4: A novel pathway of mechanotransduction in human articular chondrocytes.

Authors:  S J Millward-Sadler; M O Wright; H Lee; K Nishida; H Caldwell; G Nuki; D M Salter
Journal:  J Cell Biol       Date:  1999-04-05       Impact factor: 10.539
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