AIM: To determine whether prenatal exposure to hexachlorobenzene (HCB) has potential adverse effects on child's weight and body mass index (BMI) in a general population with no local pollution sources. METHODS: Starting from mid 1997, all mothers presenting for antenatal exposure in Menorca were recruited. Subsequently, 482 children were enrolled. HCB was measured in cord blood. Weight and height were measured at birth and at age 6.5 years. RESULTS: Children with HCB levels higher than 1.03 ng/mL in cord blood were 1.14 kg (0.38) heavier and had a higher BMI (beta= 0.80 (0.34)) than children with HCB levels lower than 0.46 ng/mL. No statistically significant associations were found in height. Children in the higher exposure group of HCB had an increased risk of 2.5 and 3.0 of being overweight and obese. Children from normal weight mothers also presented an increased risk of having higher BMI with increasing concentrations of HCB in cord serum. CONCLUSION: Prenatal exposure to HCB is associated with an increase in BMI and weight at age 6.5 years. Further studies with larger samples and longer follow-up are needed to confirm these results.
AIM: To determine whether prenatal exposure to hexachlorobenzene (HCB) has potential adverse effects on child's weight and body mass index (BMI) in a general population with no local pollution sources. METHODS: Starting from mid 1997, all mothers presenting for antenatal exposure in Menorca were recruited. Subsequently, 482 children were enrolled. HCB was measured in cord blood. Weight and height were measured at birth and at age 6.5 years. RESULTS:Children with HCB levels higher than 1.03 ng/mL in cord blood were 1.14 kg (0.38) heavier and had a higher BMI (beta= 0.80 (0.34)) than children with HCB levels lower than 0.46 ng/mL. No statistically significant associations were found in height. Children in the higher exposure group of HCB had an increased risk of 2.5 and 3.0 of being overweight and obese. Children from normal weight mothers also presented an increased risk of having higher BMI with increasing concentrations of HCB in cord serum. CONCLUSION: Prenatal exposure to HCB is associated with an increase in BMI and weight at age 6.5 years. Further studies with larger samples and longer follow-up are needed to confirm these results.
Authors: Jeanett L Tang-Péronard; Berit L Heitmann; Helle R Andersen; Ulrike Steuerwald; Philippe Grandjean; Pál Weihe; Tina K Jensen Journal: Am J Clin Nutr Date: 2013-10-23 Impact factor: 7.045
Authors: Lea A Cupul-Uicab; Mauricio Hernández-Avila; Efraín A Terrazas-Medina; Michael L Pennell; Matthew P Longnecker Journal: Environ Res Date: 2010-06-20 Impact factor: 6.498
Authors: Jerrold J Heindel; Bruce Blumberg; Mathew Cave; Ronit Machtinger; Alberto Mantovani; Michelle A Mendez; Angel Nadal; Paola Palanza; Giancarlo Panzica; Robert Sargis; Laura N Vandenberg; Frederick Vom Saal Journal: Reprod Toxicol Date: 2016-10-17 Impact factor: 3.143
Authors: Marijke de Cock; Michiel R de Boer; Eva Govarts; Nina Iszatt; Lubica Palkovicova; Marja H Lamoree; Greet Schoeters; Merete Eggesbø; Tomas Trnovec; Juliette Legler; Margot van de Bor Journal: Pediatr Res Date: 2017-06-07 Impact factor: 3.756