OBJECTIVES: To evaluate the systemic effects of moderate hypothermia (MH) and the timing of induction on acute pancreatitis (AP) and endotoxemia in rats. METHODS: The effects of MH were compared in 4 groups, that is, sham group (38 degrees C), control group (38 degrees C), early MH group (32 degrees C on administration of lipopolysaccharide [LPS]), and delayed MH group (32 degrees C 1 hour after LPS). AP and endotoxemia were induced by intramuscular injection of caerulein and intraperitoneal injection of LPS. RESULTS: Serum interleukin 6 (IL-6) in both MH groups was significantly lower than that in the control group at 3 hours. Serum interleukin 10 (IL-10) in the early MH group was significantly higher than those in the other 3 groups at 1 hour. IL-10/IL-6 ratios in both MH groups were significantly higher than that in the control group at 3 hours. Serum soluble intercellular adhesion molecule (sICAM-1) in both MH groups was significantly lower than that in the control group at 3 hours. Serum sICAM-1 in the early MH group was significantly lower than that in the delayed MH group. The tendency of pancreatic ICAM-1 was similar to that of serum sICAM-1. CONCLUSIONS: Early induction of MH might be protective against pancreatic injury and systemic inflammation in AP and endotoxemia.
OBJECTIVES: To evaluate the systemic effects of moderate hypothermia (MH) and the timing of induction on acute pancreatitis (AP) and endotoxemia in rats. METHODS: The effects of MH were compared in 4 groups, that is, sham group (38 degrees C), control group (38 degrees C), early MH group (32 degrees C on administration of lipopolysaccharide [LPS]), and delayed MH group (32 degrees C 1 hour after LPS). AP and endotoxemia were induced by intramuscular injection of caerulein and intraperitoneal injection of LPS. RESULTS: Serum interleukin 6 (IL-6) in both MH groups was significantly lower than that in the control group at 3 hours. Serum interleukin 10 (IL-10) in the early MH group was significantly higher than those in the other 3 groups at 1 hour. IL-10/IL-6 ratios in both MH groups were significantly higher than that in the control group at 3 hours. Serum soluble intercellular adhesion molecule (sICAM-1) in both MH groups was significantly lower than that in the control group at 3 hours. Serum sICAM-1 in the early MH group was significantly lower than that in the delayed MH group. The tendency of pancreatic ICAM-1 was similar to that of serum sICAM-1. CONCLUSIONS: Early induction of MH might be protective against pancreatic injury and systemic inflammation in AP and endotoxemia.
Authors: Patrick Meybohm; Matthias Gruenewald; Kai D Zacharowski; Martin Albrecht; Ralph Lucius; Nikola Fösel; Johannes Hensler; Karina Zitta; Berthold Bein Journal: Crit Care Date: 2010-02-16 Impact factor: 9.097
Authors: Kyuseok Kim; Yongqing Li; Guang Jin; Wei Chong; Baoling Liu; Jennifer Lu; Kyoungbun Lee; Marc Demoya; George C Velmahos; Hasan B Alam Journal: Resuscitation Date: 2011-08-06 Impact factor: 5.262
Authors: Rithwik Ramachandran; Eric Hyun; Liena Zhao; Tamia K Lapointe; Kevin Chapman; Christina L Hirota; Subrata Ghosh; David D McKemy; Nathalie Vergnolle; Paul L Beck; Christophe Altier; Morley D Hollenberg Journal: Proc Natl Acad Sci U S A Date: 2013-04-17 Impact factor: 11.205
Authors: Matthew B A Harmon; Nanon F L Heijnen; Sanne de Bruin; Niek H Sperna Weiland; Joost C M Meijers; Anita M de Boer; Marcus J Schultz; Janneke Horn; Nicole P Juffermans Journal: Br J Anaesth Date: 2021-04-23 Impact factor: 9.166
Authors: Michael Frink; Sascha Flohé; Martijn van Griensven; Philipp Mommsen; Frank Hildebrand Journal: Mediators Inflamm Date: 2012-03-13 Impact factor: 4.711