BACKGROUND/AIMS: The development of acute renal failure (ARF) is a very rare complication in patients with acute hepatitis A (AHA). METHODS: We retrospectively investigated the overall incidence, risk factors, and clinical outcomes of ARF associated with AHA. Diagnosis of AHA was made according to the typical hepatitis symptoms and positivity of immunoglobulin M anti-hepatitis A virus in 208 patients with AHA. RESULTS: ARF was noted in 12 (5.7%) patients, and dialysis was required in 8 (66%) patients. The median duration of hospitalization for patients with ARF was 18 days (range, 6-50 days). The development of ARF was observed in older patients (p = 0.004) and in patients with diabetes (p = 0.001), excessive alcohol consumption (p = 0.01), prolonged international normalized ratio (p = 0.019), and elevated aspartate aminotransferase concentration (p = 0.034). Multivariate analysis revealed that old age (odds ratio, OR, 1.2), elevated aspartate aminotransferase concentration (OR, 1.05), and diabetes (OR, 18.5) were independent risk factors for ARF (each p < 0.001). The prognosis of patients with ARF was good, and renal function recovered completely. CONCLUSION: ARF associated with AHA is not rare, and the possibility of AHA should be considered in patients with ARF with hepatic dysfunction. Copyright 2008 S. Karger AG, Basel.
BACKGROUND/AIMS: The development of acute renal failure (ARF) is a very rare complication in patients with acute hepatitis A (AHA). METHODS: We retrospectively investigated the overall incidence, risk factors, and clinical outcomes of ARF associated with AHA. Diagnosis of AHA was made according to the typical hepatitis symptoms and positivity of immunoglobulin M anti-hepatitis A virus in 208 patients with AHA. RESULTS:ARF was noted in 12 (5.7%) patients, and dialysis was required in 8 (66%) patients. The median duration of hospitalization for patients with ARF was 18 days (range, 6-50 days). The development of ARF was observed in older patients (p = 0.004) and in patients with diabetes (p = 0.001), excessive alcohol consumption (p = 0.01), prolonged international normalized ratio (p = 0.019), and elevated aspartate aminotransferase concentration (p = 0.034). Multivariate analysis revealed that old age (odds ratio, OR, 1.2), elevated aspartate aminotransferase concentration (OR, 1.05), and diabetes (OR, 18.5) were independent risk factors for ARF (each p < 0.001). The prognosis of patients with ARF was good, and renal function recovered completely. CONCLUSION:ARF associated with AHA is not rare, and the possibility of AHA should be considered in patients with ARF with hepatic dysfunction. Copyright 2008 S. Karger AG, Basel.
Authors: Eunjung Cho; Inhye Cha; Kichul Yoon; Ha Na Yang; Hye Won Kim; Myung-Gyu Kim; Sang-Kyung Jo; Won Yong Cho; Hyoung Kyu Kim Journal: J Korean Med Sci Date: 2010-09-17 Impact factor: 2.153
Authors: Christophe Masset; Paul Le Turnier; Céline Bressollette-Bodin; Karine Renaudin; François Raffi; Jacques Dantal Journal: Int J Mol Sci Date: 2022-10-10 Impact factor: 6.208