| Literature DB >> 18662874 |
Jun Tang1, Toshihiro Hamajima, Masato Nakano, Hideyuki Sato, Scott H Dickerson, Karen E Lackey.
Abstract
The synthesis of a 7-azaindole series of novel, potent B-Raf kinase inhibitors using knowledge-based design was carried out. Compound 6h exhibits not only excellent potency in both the enzyme assay (IC(50)=2.5 nM) and the cellular assay (IC(50)=63 nM), but also has an outstanding selectivity profile against other kinases.Entities:
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Year: 2008 PMID： 18662874 DOI： 10.1016/j.bmcl.2008.07.019
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823