| Literature DB >> 18662544 |
Yelena V Budovskaya1, Kendall Wu, Lucinda K Southworth, Min Jiang, Patricia Tedesco, Thomas E Johnson, Stuart K Kim.
Abstract
To define the C. elegans aging process at the molecular level, we used DNA microarray experiments to identify a set of 1294 age-regulated genes and found that the GATA transcription factors ELT-3, ELT-5, and ELT-6 are responsible for age regulation of a large fraction of these genes. Expression of elt-5 and elt-6 increases during normal aging, and both of these GATA factors repress expression of elt-3, which shows a corresponding decrease in expression in old worms. elt-3 regulates a large number of downstream genes that change expression in old age, including ugt-9, col-144, and sod-3. elt-5(RNAi) and elt-6(RNAi) worms have extended longevity, indicating that elt-3, elt-5, and elt-6 play an important functional role in the aging process. These results identify a transcriptional circuit that guides the rapid aging process in C. elegans and indicate that this circuit is driven by drift of developmental pathways rather than accumulation of damage.Entities:
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Year: 2008 PMID： 18662544 PMCID： PMC4719053 DOI： 10.1016/j.cell.2008.05.044
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582