Gang Han1, Rui Bi, Quan Le, Lin-Lin Zhao, Yue Dong, Qing-Hui Lin. 1. Tangshan Key Laboratory of New Drug Research, Pharmaceutical Department of North China Coal Medical College, Tangshan 063000, China. tsyxhg@163.com
Abstract
OBJECTIVE: To investigate effect of demethoxycurcumin on stability of curcumin. METHODS: To add the demethoxycurcumin to pure curcumin, the change of curcumin was determined by HPLC and the dynamics of curcumin degradation was investigated. RESULT: The stability both obtained from alcohol and demethoxycurcumin improved the stabilization of curcumin, the demi-period of curcumin prolonged with the addition of demethoxycurcumin. CONCLUSION: The commixture of curcumin and demethoxycurcumin are more stable than pure curcumin at the same conditions. Stability of curcumin is improved by demethoxycurcumin,it is crude stabilizing agent.
OBJECTIVE: To investigate effect of demethoxycurcumin on stability of curcumin. METHODS: To add the demethoxycurcumin to pure curcumin, the change of curcumin was determined by HPLC and the dynamics of curcumin degradation was investigated. RESULT: The stability both obtained from alcohol and demethoxycurcumin improved the stabilization of curcumin, the demi-period of curcumin prolonged with the addition of demethoxycurcumin. CONCLUSION: The commixture of curcumin and demethoxycurcumin are more stable than pure curcumin at the same conditions. Stability of curcumin is improved by demethoxycurcumin,it is crude stabilizing agent.