Literature DB >> 186616

Effect of allelic substitutions at the hairless locus on endogenous ecotropic murine leukemia virus titers and leukemogenesis.

H J Heiniger, R J Huebner, H Meier.   

Abstract

Leukemia-prone hairless (HRS/J; hr/hr) mice had significantly higher leukemia virus titers than did the leukemia-resistant nonmutants (hr/ + and +/+). This difference was ascribed to the allelic substitution at a single gene locus; at 6 months of age it averaged 13-fold, immediately preceding the large divergence in leukemia incidence between the mutant and nonmutant mice.

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Year:  1976        PMID： 186616     DOI： 10.1093/jnci/56.5.1073

Source DB:  PubMed          Journal:  J Natl Cancer Inst        ISSN： 0027-8874            Impact factor:   13.506


  2 in total

1.  Immune competency of a hairless mouse strain for improved preclinical studies in genetically engineered mice.

Authors:  Beverly S Schaffer; Marcia H Grayson; Joy M Wortham; Courtney B Kubicek; Amanda T McCleish; Suresh I Prajapati; Laura D Nelon; Michelle M Brady; Inkyung Jung; Tohru Hosoyama; Leslea M Sarro; Martha A Hanes; Brian P Rubin; Joel E Michalek; Charles B Clifford; Anthony J Infante; Charles Keller
Journal:  Mol Cancer Ther       Date:  2010-07-27       Impact factor: 6.261

2.  Insertional mutation of the hairless locus on mouse chromosome 14.

Authors:  J M Jones; J T Elder; K Simin; S A Keller; M H Meisler
Journal:  Mamm Genome       Date:  1993-11       Impact factor: 2.957
  2 in total

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