Literature DB >> 18661346

Importance of hyaluronan-CD44 interactions in inflammation and tumorigenesis.

Paraskevi Heldin1, Eugenia Karousou, Berit Bernert, Helena Porsch, Koichi Nishitsuka, Spyros S Skandalis.   

Abstract

Hyaluronan is an apparently simple polysaccharide that is responsible for tissue hydration but also stimulates cell proliferation, migration, and differentiation via binding to cell surface receptors, such as CD44. The amounts of hyaluronan increase during inflammation and tumorigenesis through the action of chemokines and growth factors. This review discusses some of the evidence that hyaluronan-CD44 complexes trigger signaling cascades that modulate inflammation and tumor progression.

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Year:  2008        PMID： 18661346     DOI： 10.1080/03008200802143323

Source DB:  PubMed          Journal:  Connect Tissue Res        ISSN： 0300-8207            Impact factor:   3.417


  37 in total

1.  Role of CD44 in the organization of keratinocyte pericellular hyaluronan.

Authors:  Sanna Pasonen-Seppänen; Juha M T Hyttinen; Kirsi Rilla; Tiina Jokela; Paul W Noble; Markku Tammi; Raija Tammi
Journal:  Histochem Cell Biol       Date:  2011-11-10       Impact factor: 4.304

2.  Chronic UVR causes increased immunostaining of CD44 and accumulation of hyaluronan in mouse epidermis.

Authors:  Hanna Siiskonen; Kari Törrönen; Timo Kumlin; Kirsi Rilla; Markku I Tammi; Raija H Tammi
Journal:  J Histochem Cytochem       Date:  2011-08-10       Impact factor: 2.479

3.  CD44 receptor unfolding enhances binding by freeing basic amino acids to contact carbohydrate ligand.

Authors:  Amanda J Favreau; Christina E Faller; Olgun Guvench
Journal:  Biophys J       Date:  2013-09-03       Impact factor: 4.033

Review 4.  Extracellular matrix molecules: potential targets in pharmacotherapy.

Authors:  Hannu Järveläinen; Annele Sainio; Markku Koulu; Thomas N Wight; Risto Penttinen
Journal:  Pharmacol Rev       Date:  2009-06       Impact factor: 25.468

Review 5.  Hyaluronan-CD44 interactions as potential targets for cancer therapy.

Authors:  Suniti Misra; Paraskevi Heldin; Vincent C Hascall; Nikos K Karamanos; Spyros S Skandalis; Roger R Markwald; Shibnath Ghatak
Journal:  FEBS J       Date:  2011-03-25       Impact factor: 5.542

6.  Intermediate Molecular Mass Hyaluronan and CD44 Receptor Interactions Enhance Neutrophil Phagocytosis and IL-8 Production via p38- and ERK1/2-MAPK Signalling Pathways.

Authors:  Cheng-Hsun Lu; Chia-Huei Lin; Ko-Jen Li; Chieh-Yu Shen; Cheng-Han Wu; Yu-Min Kuo; Ting-Syuan Lin; Chia-Li Yu; Song-Chou Hsieh
Journal:  Inflammation       Date:  2017-10       Impact factor: 4.092

7.  Lipid raft association restricts CD44-ezrin interaction and promotion of breast cancer cell migration.

Authors:  Simona Donatello; Irina S Babina; Lee D Hazelwood; Arnold D K Hill; Ivan R Nabi; Ann M Hopkins
Journal:  Am J Pathol       Date:  2012-09-29       Impact factor: 4.307

8.  Iatrogenic extracellular matrix disruption as a local trigger for postoperative ileus.

Authors:  Johannes Chang; Sven Wehner; Nico Schäfer; Maria Sioutis; Stephan Bortscher; Andreas Hirner; Jörg C Kalff; Anthony J Bauer; Marcus Overhaus
Journal:  J Surg Res       Date:  2012-06-01       Impact factor: 2.192

9.  Polyinosine-polycytidylic acid stimulates versican accumulation in the extracellular matrix promoting monocyte adhesion.

Authors:  Susan Potter-Perigo; Pamela Y Johnson; Stephen P Evanko; Christina K Chan; Kathleen R Braun; Thomas S Wilkinson; Leonard C Altman; Thomas N Wight
Journal:  Am J Respir Cell Mol Biol       Date:  2009-08-28       Impact factor: 6.914

10.  Esterified hyaluronic acid and autologous bone in the surgical correction of the infra-bone defects.

Authors:  Andrea Ballini; Stefania Cantore; Saverio Capodiferro; Felice Roberto Grassi
Journal:  Int J Med Sci       Date:  2009-02-26       Impact factor: 3.738
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