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Literature DB >> 18661339

Dysregulation of matrix metalloproteinases and their tissue inhibitors by S100A4.

Renate Elenjord¹, Hilde Ljones, Elisabeth Sundkvist, Thrina Loennechen, Jan Olof Winberg.

Abstract

The S100A4 protein as well as the matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are associated with diseases such as arthritis and cancer. This mini review focuses on in vitro and in vivo studies indicating S100A4 involvement in regulation of MMPs and TIMPs, and the biological and pathobiological consequences of this regulation.

Entities: Disease Gene

Mesh：

Substances：

Year: 2008 PMID： 18661339 DOI： 10.1080/03008200802143125

Source DB: PubMed Journal: Connect Tissue Res ISSN： 0300-8207 Impact factor: 3.417

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Cited

8 in total

1. S100A4 expression in xenograft tumors of human carcinoma cell lines is induced by the tumor microenvironment.

Authors: Hilde Ljones Wetting; Elin Hadler-Olsen; Synnøve Magnussen; Oddveig Rikardsen; Sonja E Steigen; Elisabeth Sundkvist; Thrina Loennechen; Premasany Kanapathippillai; Hanne Kildalsen; Jan-Olof Winberg; Lars Uhlin-Hansen; Gunbjørg Svineng
Journal: Am J Pathol Date: 2011-05 Impact factor: 4.307

2. Metastasin S100A4 is a mediator of sex hormone-dependent formation of the cortical bone.

Authors: Malin C Erlandsson; Li Bian; Ing-Marie Jonsson; Karin M Andersson; Maria I Bokarewa
Journal: Mol Endocrinol Date: 2013-06-24

3. Nifedipine and phenytoin induce matrix synthesis, but not proliferation, in intact human gingival connective tissue ex vivo.

Authors: Shawna S Kim; Sarah Michelsons; Kendal Creber; Michael J Rieder; Douglas W Hamilton
Journal: J Cell Commun Signal Date: 2015-08-23 Impact factor: 5.782

Review 4. Functions of S100 proteins.

Authors: R Donato; B R Cannon; G Sorci; F Riuzzi; K Hsu; D J Weber; C L Geczy
Journal: Curr Mol Med Date: 2013-01 Impact factor: 2.222

Dysregulation of matrix metalloproteinases and their tissue inhibitors by S100A4.

1. S100A4 expression in xenograft tumors of human carcinoma cell lines is induced by the tumor microenvironment.

2. Metastasin S100A4 is a mediator of sex hormone-dependent formation of the cortical bone.

3. Nifedipine and phenytoin induce matrix synthesis, but not proliferation, in intact human gingival connective tissue ex vivo.

Review 4. Functions of S100 proteins.

5. Systemic shRNA mediated knock down of S100A4 in colorectal cancer xenografted mice reduces metastasis formation.

6. Shotgun Proteomics for the Identification and Profiling of the Tear Proteome of Keratoconus Patients.

Review 7. S100 Proteins in Fatty Liver Disease and Hepatocellular Carcinoma.

8. MiR-296-5p ameliorates deep venous thrombosis by inactivating S100A4.