Literature DB >> 18661203

Gene expression profile changes correlated with lymph node metastasis in oral squamous cell carcinoma.

Haruhiko Kashiwazaki1, Nur Mohammad Monsur Hassan, Jun-Ichi Hamada, Tetsuya Moriuchi, Yutaka Yamazaki, Kanchu Tei, Yasunori Totsuka, Nobuo Inoue.   

Abstract

The purpose of this research was to identify biomarkers for predicting cervical lymph node metastasis in oral squamous cell carcinoma (OSCC). We surveyed the expressions of 1289 cancer-related genes in 41 cases of OSCC by cDNA array analysis. We extracted genes upregulated or downregulated in their expression in association with lymph node metastasis. Of 1289 cancer-related genes, we identified 39 genes differentially expressed in OSCC with or without lymph node metastasis. Expression levels of 9 genes were lower, and those of 30 genes were higher, in node-positive cases. The genes expressed at higher levels in node-positive cases included angiogenesis-related molecules, cell adhesion molecules, and proteolytic enzymes. We suggest that these characteristic genes could provide, if verifiable, useful information for predicting the risk of lymph node metastasis in OSCC.

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Year:  2008        PMID： 18661203     DOI： 10.1007/s10266-008-0084-1

Source DB:  PubMed          Journal:  Odontology        ISSN： 1618-1247            Impact factor:   2.634


  25 in total

1.  Expression of vascular endothelial growth factor-C correlates with the lymphatic microvessel density and the nodal status in oral squamous cell cancer.

Authors:  Roland Sedivy; Johann Beck-Mannagetta; C Haverkampf; Walter Battistutti; Selma Hönigschnabl
Journal:  J Oral Pathol Med       Date:  2003-09       Impact factor: 4.253

2.  Gene-expression profile changes correlated with tumor progression and lymph node metastasis in esophageal cancer.

Authors:  Eiji Tamoto; Mitsuhiro Tada; Katsuhiko Murakawa; Minoru Takada; Gaku Shindo; Ken-ichi Teramoto; Akihiro Matsunaga; Kazuteru Komuro; Motoshi Kanai; Akiko Kawakami; Yoshie Fujiwara; Nozomi Kobayashi; Katsutoshi Shirata; Norihiro Nishimura; Shun-ichi Okushiba; Satoshi Kondo; Jun-ichi Hamada; Takashi Yoshiki; Tetsuya Moriuchi; Hiroyuki Katoh
Journal:  Clin Cancer Res       Date:  2004-06-01       Impact factor: 12.531

3.  Clinical value of genetically diagnosed lymph node micrometastasis for patients with oral squamous cell carcinoma.

Authors:  Yutaka Yamazaki; Itsuo Chiba; Atsuko Hirai; Chiharu Satoh; Noriyuki Sakakibara; Ken-ichi Notani; Tadashi Iizuka; Yasunori Totsuka
Journal:  Head Neck       Date:  2005-08       Impact factor: 3.147

4.  Tenascin-W is found in malignant mammary tumors, promotes alpha8 integrin-dependent motility and requires p38MAPK activity for BMP-2 and TNF-alpha induced expression in vitro.

Authors:  Arnaud Scherberich; Richard P Tucker; Martin Degen; Marianne Brown-Luedi; Anne-Catherine Andres; Ruth Chiquet-Ehrismann
Journal:  Oncogene       Date:  2005-02-24       Impact factor: 9.867

5.  Clinical significance of matrix metalloproteinase-7 expression in esophageal carcinoma.

Authors:  K Yamashita; M Mori; T Shiraishi; K Shibuta; K Sugimachi
Journal:  Clin Cancer Res       Date:  2000-03       Impact factor: 12.531

6.  Prediction of lymph node metastasis and perineural invasion of biliary tract cancer by selected features from cDNA array data.

Authors:  Katsuhiko Murakawa; Mitsuhiro Tada; Minoru Takada; Eiji Tamoto; Gaku Shindoh; Ken-ichi Teramoto; Akihiro Matsunaga; Kazuteru Komuro; Motoshi Kanai; Akiko Kawakami; Yoshie Fujiwara; Nozomi Kobayashi; Katsutoshi Shirata; Norihiro Nishimura; Shun-ichi Okushiba; Satoshi Kondo; Jun-ichi Hamada; Hiroyuki Katoh; Takashi Yoshiki; Tetsuya Moriuchi
Journal:  J Surg Res       Date:  2004-12       Impact factor: 2.192

7.  Expression of matrix metalloproteinase-3 in stage I and II squamous cell carcinoma of the oral cavity.

Authors:  J Kusukawa; Y Sasaguri; M Morimatsu; T Kameyama
Journal:  J Oral Maxillofac Surg       Date:  1995-05       Impact factor: 1.895

8.  Progressive loss of PAX9 expression correlates with increasing malignancy of dysplastic and cancerous epithelium of the human oesophagus.

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Journal:  J Pathol       Date:  2002-07       Impact factor: 7.996

9.  Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells.

Authors:  B Olofsson; E Korpelainen; M S Pepper; S J Mandriota; K Aase; V Kumar; Y Gunji; M M Jeltsch; M Shibuya; K Alitalo; U Eriksson
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-29       Impact factor: 11.205

10.  Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release?

Authors:  G Deng; S A Curriden; S Wang; S Rosenberg; D J Loskutoff
Journal:  J Cell Biol       Date:  1996-09       Impact factor: 10.539
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  8 in total

1.  Increased glucose metabolism by FDG-PET correlates with reduced tumor angiogenesis in oral squamous cell carcinoma.

Authors:  Mikiko Nakamura; Yoshimasa Kitagawa; Yutaka Yamazaki; Hironobu Hata; Motoko Kotsuji; Yasuhisa Fujibayashi; Hidehiko Okazawa; Yoshiharu Yonekura; Kazuo Sano
Journal:  Odontology       Date:  2011-05-13       Impact factor: 2.634

2.  Gene Expression Signatures of Lymph Node Metastasis in Oral Cancer: Molecular Characteristics and Clinical Significances.

Authors:  Xiqiang Liu; Antonia Kolokythas; Jianguang Wang; Hongzhang Huang; Xiaofeng Zhou
Journal:  Curr Cancer Ther Rev       Date:  2010-11-01

3.  Prognostic significance and tumor biology of regional lymph node disease in patients with rhabdomyosarcoma: a report from the Children's Oncology Group.

Authors:  David A Rodeberg; Norbert Garcia-Henriquez; Elizabeth R Lyden; Elai Davicioni; David M Parham; Stephen X Skapek; Andrea A Hayes-Jordan; Sarah S Donaldson; Kenneth L Brown; Timothy J Triche; William H Meyer; Douglas S Hawkins
Journal:  J Clin Oncol       Date:  2011-02-28       Impact factor: 44.544

4.  Screen and analysis of key disease genes for precancerous lesions of oral buccal mucosa induced by DMBA in golden hamsters.

Authors:  Dan Chen; Kai Yang; Guodong Zhang; Jie Mei; Li Xiang
Journal:  Oncol Lett       Date:  2010-12-23       Impact factor: 2.967

5.  No mutations found in exon 2 of gene p16CDKN2A during rat tongue carcinogenesis induced by 4-nitroquinoline-1-oxide.

Authors:  Eliana Maria Minicucci; Glenda Nicioli da Silva; Daniel Araki Ribeiro; Daisy Maria Favero Salvadori
Journal:  J Mol Histol       Date:  2009-03-03       Impact factor: 2.611

6.  Revisiting the transcriptional analysis of primary tumours and associated nodal metastases with enhanced biological and statistical controls: application to thyroid cancer.

Authors:  M Tarabichi; M Saiselet; C Trésallet; C Hoang; D Larsimont; G Andry; C Maenhaut; V Detours
Journal:  Br J Cancer       Date:  2015-05-12       Impact factor: 7.640

7.  Insulin-like growth factor-independent insulin-like growth factor binding protein 3 promotes cell migration and lymph node metastasis of oral squamous cell carcinoma cells by requirement of integrin β1.

Authors:  Yi-Chen Yen; Jenn-Ren Hsiao; Shih Sheng Jiang; Jeffrey S Chang; Ssu-Han Wang; Ying-Ying Shen; Chung-Hsing Chen; I-Shou Chang; Jang-Yang Chang; Ya-Wen Chen
Journal:  Oncotarget       Date:  2015-12-08

8.  Systematic analysis of genes involved in oral cancer metastasis to lymph nodes.

Authors:  Xing'an Zhang; Lanfang Zhang; Xiaoyao Tan; Ying Lin; Xinsheng Han; Huadong Wang; Huawei Ming; Qiujiang Li; Kang Liu; Gang Feng
Journal:  Cell Mol Biol Lett       Date:  2018-11-15       Impact factor: 5.787
  8 in total

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