Literature DB >> 18658289

Escherichia coli constructs expressing human or porcine enterotoxins induce identical diarrheal diseases in a piglet infection model.

Weiping Zhang1, Donald C Robertson, Chengxian Zhang, Wei Bai, Mojun Zhao, David H Francis.   

Abstract

To develop a piglet model for studying diarrheal disease and developing vaccines, we challenged gnotobiotic piglets with isogenic Escherichia coli strains constructed to express porcine 987P(F6) fimbriae and a heat-labile or a heat-stable enterotoxin to examine clinical outcomes. Piglets developed identical diarrheal diseases when inoculated with constructs expressing human or porcine enterotoxins.

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Year:  2008        PMID： 18658289      PMCID： PMC2547035          DOI： 10.1128/AEM.00893-08

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  35 in total

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Journal:  Infect Immun       Date:  1989-01       Impact factor: 3.441

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Authors:  Hans Steinsland; Palle Valentiner-Branth; Michael Perch; Francisco Dias; Thea K Fischer; Peter Aaby; Kåre Mølbak; Halvor Sommerfelt
Journal:  J Infect Dis       Date:  2002-11-18       Impact factor: 5.226

6.  Development of a competitive enzyme-linked immunosorbent assay (ELISA) for Escherichia coli heat-stable enterotoxin (STa).

Authors:  D E Lockwood; D C Robertson
Journal:  J Immunol Methods       Date:  1984-12-31       Impact factor: 2.303

Review 7.  Microbial-gut interactions in health and disease. Progress in enteric vaccine development.

Authors:  Ann-Mari Svennerholm; Duncan Steele
Journal:  Best Pract Res Clin Gastroenterol       Date:  2004-04       Impact factor: 3.043

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Authors:  P A Ristaino; M M Levine; C R Young
Journal:  J Clin Microbiol       Date:  1983-10       Impact factor: 5.948

9.  Different pig phenotypes affect adherence of Escherichia coli to jejunal brush borders by K88ab, K88ac, or K88ad antigen.

Authors:  I G Bijlsma; A de Nijs; C van der Meer; J F Frik
Journal:  Infect Immun       Date:  1982-09       Impact factor: 3.441

10.  Prevalence of toxin types and colonization factors in enterotoxigenic Escherichia coli isolated during a 2-year period from diarrheal patients in Bangladesh.

Authors:  F Qadri; S K Das; A S Faruque; G J Fuchs; M J Albert; R B Sack; A M Svennerholm
Journal:  J Clin Microbiol       Date:  2000-01       Impact factor: 5.948
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  24 in total

Review 1.  Animal Enterotoxigenic Escherichia coli.

Authors:  J Daniel Dubreuil; Richard E Isaacson; Dieter M Schifferli
Journal:  EcoSal Plus       Date:  2016-10

2.  F4- and F18-Positive Enterotoxigenic Escherichia coli Isolates from Diarrhea of Postweaning Pigs: Genomic Characterization.

Authors:  Vanesa García; Michela Gambino; Karl Pedersen; Svend Haugegaard; John Elmerdahl Olsen; Ana Herrero-Fresno
Journal:  Appl Environ Microbiol       Date:  2020-11-10       Impact factor: 4.792

3.  Characterization of immunological cross-reactivity between enterotoxigenic Escherichia coli heat-stable toxin and human guanylin and uroguanylin.

Authors:  Arne M Taxt; Yuleima Diaz; Amélie Bacle; Cédric Grauffel; Nathalie Reuter; Rein Aasland; Halvor Sommerfelt; Pål Puntervoll
Journal:  Infect Immun       Date:  2014-04-28       Impact factor: 3.441

4.  Characterization of heat-stable (STa) toxoids of enterotoxigenic Escherichia coli fused to double mutant heat-labile toxin peptide in inducing neutralizing Anti-STa antibodies.

Authors:  Xiaosai Ruan; Donald C Robertson; James P Nataro; John D Clements; Weiping Zhang
Journal:  Infect Immun       Date:  2014-02-18       Impact factor: 3.441

5.  Neutralizing Anti-Heat-Stable Toxin (STa) Antibodies Derived from Enterotoxigenic Escherichia coli Toxoid Fusions with STa Proteins Containing N12S, L9A/N12S, or N12S/A14T Mutations Show Little Cross-Reactivity with Guanylin or Uroguanylin.

Authors:  Qiangde Duan; Jiachen Huang; Nan Xiao; Hyesuk Seo; Weiping Zhang
Journal:  Appl Environ Microbiol       Date:  2018-01-02       Impact factor: 4.792

6.  Escherichia coli K88ac fimbriae expressing heat-labile and heat-stable (STa) toxin epitopes elicit antibodies that neutralize cholera toxin and STa toxin and inhibit adherence of K88ac fimbrial E. coli.

Authors:  Chengxian Zhang; Weiping Zhang
Journal:  Clin Vaccine Immunol       Date:  2010-10-27

7.  Functional diversity of heat-labile toxins (LT) produced by enterotoxigenic Escherichia coli: differential enzymatic and immunological activities of LT1 (hLT) AND LT4 (pLT).

Authors:  Juliana F Rodrigues; Camila Mathias-Santos; Maria Elisabete Sbrogio-Almeida; Jaime H Amorim; Joaquim Cabrera-Crespo; Andrea Balan; Luís C S Ferreira
Journal:  J Biol Chem       Date:  2010-12-06       Impact factor: 5.157

8.  A tripartite fusion, FaeG-FedF-LT(192)A2:B, of enterotoxigenic Escherichia coli (ETEC) elicits antibodies that neutralize cholera toxin, inhibit adherence of K88 (F4) and F18 fimbriae, and protect pigs against K88ac/heat-labile toxin infection.

Authors:  Xiaosai Ruan; Mei Liu; Thomas A Casey; Weiping Zhang
Journal:  Clin Vaccine Immunol       Date:  2011-08-03

9.  Heat-labile- and heat-stable-toxoid fusions (LTR₁₉₂G-STaP₁₃F) of human enterotoxigenic Escherichia coli elicit neutralizing antitoxin antibodies.

Authors:  Mei Liu; Xiaosai Ruan; Chengxian Zhang; Steve R Lawson; David E Knudsen; James P Nataro; Donald C Robertson; Weiping Zhang
Journal:  Infect Immun       Date:  2011-07-25       Impact factor: 3.441

10.  Little heterogeneity among genes encoding heat-labile and heat-stable toxins of enterotoxigenic Escherichia coli strains isolated from diarrheal pigs.

Authors:  Chengxian Zhang; Dana Rausch; Weiping Zhang
Journal:  Appl Environ Microbiol       Date:  2009-08-14       Impact factor: 4.792
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