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Literature DB >> 18658049

Atheroprotective effect of human apolipoprotein A5 in a mouse model of mixed dyslipidemia.

Roxane M Mansouri¹, Eric Baugé, Philippe Gervois, Jamila Fruchart-Najib, Catherine Fiévet, Bart Staels, Jean-Charles Fruchart.

Abstract

Hypertriglyceridemia is an independent risk factor for coronary artery disease. Because apolipoprotein (Apo)A5 regulates plasma triglyceride levels, we investigated the impact of human (h)ApoA5 on atherogenesis. The influence of hApoA5 transgenic expression was studied in the ApoE2 knock-in mouse model of mixed dyslipidemia. Our results demonstrate that hApoA5 lowers plasma triglyceride levels in Western diet-fed ApoE2 knock-in mice. Moreover, atherosclerotic lesion development was significantly decreased in the hApoA5 transgenic mice. Finally, pharmacologic activation of hApoA5 expression by the peroxisome proliferator-activated receptor-alpha agonist fenofibrate resulted in an enhanced atheroprotection. These results identify an atheroprotective role of hApoA5 in a mouse model of mixed dyslipidemia.

Entities: Chemical Disease Gene Species

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Year: 2008 PMID： 18658049 DOI： 10.1161/CIRCRESAHA.108.179861

Source DB: PubMed Journal: Circ Res ISSN： 0009-7330 Impact factor: 17.367

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Cited

15 in total

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Authors: Stephen J Nicholls; A Michael Lincoff; Dianna Bash; Christie M Ballantyne; Philip J Barter; Michael H Davidson; John J P Kastelein; Wolfgang Koenig; Darren K McGuire; Dariush Mozaffarian; Terje R Pedersen; Paul M Ridker; Kausik Ray; Björn W Karlson; Torbjörn Lundström; Kathy Wolski; Steven E Nissen
Journal: Clin Cardiol Date: 2018-09-28 Impact factor: 2.882

2. Beyond genome-wide association studies: the usefulness of mouse genetics in understanding the complex etiology of atherosclerosis.

Authors: Carrie L Welch
Journal: Arterioscler Thromb Vasc Biol Date: 2012-02 Impact factor: 8.311

Atheroprotective effect of human apolipoprotein A5 in a mouse model of mixed dyslipidemia.

Review 1. Assessment of omega-3 carboxylic acids in statin-treated patients with high levels of triglycerides and low levels of high-density lipoprotein cholesterol: Rationale and design of the STRENGTH trial.

2. Beyond genome-wide association studies: the usefulness of mouse genetics in understanding the complex etiology of atherosclerosis.

3. Gene transfer of apolipoprotein A-V improves the hypertriglyceridemic phenotype of apoa5 (-/-) mice.

Review 4. Influence of apolipoprotein A-V on the metabolic fate of triacylglycerol.

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6. Apolipoproteins E and AV mediate lipoprotein clearance by hepatic proteoglycans.

7. Cloning and characterization of a novel apolipoprotein gene, apolipoprotein AV, in tree shrews.

Review 8. The paradox of ApoA5 modulation of triglycerides: evidence from clinical and basic research.

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10. Diet-induced renal changes in Zucker rats are ameliorated by the superoxide dismutase mimetic TEMPOL.