BACKGROUND AND PURPOSE: The diagnosis of ischemic stroke can be difficult. CT may be normal in the early stages of ischemic stroke or in patients with minor symptoms and MR is not always possible. Many blood markers have been proposed for the diagnosis of stroke in the acute setting. METHODS: We have systematically reviewed the diagnostic literature and found 21 studies testing 58 single biomarkers and 7 panels of several biomarkers. Although all show either a high sensitivity or specificity, there are limitations in the design and reporting of all the studies that mean no biomarker can be recommended for use in clinical practice. CONCLUSIONS: We make recommendations for the design and reporting of studies of diagnostic blood biomarkers in stroke.
BACKGROUND AND PURPOSE: The diagnosis of ischemic stroke can be difficult. CT may be normal in the early stages of ischemic stroke or in patients with minor symptoms and MR is not always possible. Many blood markers have been proposed for the diagnosis of stroke in the acute setting. METHODS: We have systematically reviewed the diagnostic literature and found 21 studies testing 58 single biomarkers and 7 panels of several biomarkers. Although all show either a high sensitivity or specificity, there are limitations in the design and reporting of all the studies that mean no biomarker can be recommended for use in clinical practice. CONCLUSIONS: We make recommendations for the design and reporting of studies of diagnostic blood biomarkers in stroke.
Authors: E Santamarina; A Penalba; T García-Berrocoso; P Delgado; M Quintana; T González-Alujas; M Ribó; O Maisterra; C A Molina; A Evangelista; J Alvarez-Sabín; J Montaner Journal: J Neurol Date: 2012-05-17 Impact factor: 4.849
Authors: L Servaas Dolmans; Frans H Rutten; Niels C T Koenen; Marie-Louise E L Bartelink; Johannes B Reitsma; L Jaap Kappelle; Arno W Hoes Journal: Cerebrovasc Dis Date: 2019-08-30 Impact factor: 2.762
Authors: Zhiqun Zhang; Stefania Mondello; Firas Kobeissy; Richard Rubenstein; Jackson Streeter; Ronald L Hayes; Kevin K W Wang Journal: Transl Stroke Res Date: 2011-12-07 Impact factor: 6.829
Authors: Juha Onatsu; Mikko Taina; Pirjo Mustonen; Marja Hedman; Antti Muuronen; Otso Arponen; Miika Korhonen; Pekka Jäkälä; Ritva Vanninen; Kari Pulkki Journal: In Vivo Date: 2017 May-Jun Impact factor: 2.155