Literature DB >> 18657885

Synthesis and QSAR evaluation of 2-(substituted phenyl)-1H-benzimidazoles and [2-(substituted phenyl)-benzimidazol-1-yl]-pyridin-3-yl-methanones.

Deepika Sharma1, Balasubramanian Narasimhan, Pradeep Kumar, Abraham Jalbout.   

Abstract

A series of 2-(substituted phenyl)-1H-benzimidazole (1-10) and [2-(substituted phenyl)-benzimidazol-1-yl]-pyridin-3-yl-methanone (11-19) derivatives were synthesized and tested in vitro for their antimicrobial activity. The results of QSAR investigation indicated the importance of molecular descriptors, dipole moment (mu), log of octanol water partition coefficient (logP) and second order molecular connectivity index ((2)chi) in describing the antimicrobial activity of the synthesized compounds.

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Year:  2008        PMID： 18657885     DOI： 10.1016/j.ejmech.2008.06.009

Source DB:  PubMed          Journal:  Eur J Med Chem        ISSN： 0223-5234            Impact factor:   6.514


  9 in total

1.  Synthesis and quantitative structure activity relationship (QSAR) of arylidene (benzimidazol-1-yl)acetohydrazones as potential antibacterial agents.

Authors:  Yeldez El-Kilany; Nariman M Nahas; Mariam A Al-Ghamdi; Mohamed E I Badawy; El Sayed H El Ashry
Journal:  World J Microbiol Biotechnol       Date:  2014-10-11       Impact factor: 3.312

2.  A simple, efficient synthesis of 2-aryl benzimidazoles using silica supported periodic Acid catalyst and evaluation of anticancer activity.

Authors:  Vyankat A Sontakke; Sougata Ghosh; Pravin P Lawande; Balu A Chopade; Vaishali S Shinde
Journal:  ISRN Org Chem       Date:  2013-04-24

3.  Antimicrobial Activity of Some Novel Armed Thiophene Derivatives and Petra/Osiris/Molinspiration (POM) Analyses.

Authors:  Yahia Nasser Mabkhot; Fatima Alatibi; Nahed Nasser E El-Sayed; Salim Al-Showiman; Nabila Abdelshafy Kheder; Abdul Wadood; Abdur Rauf; Saud Bawazeer; Taibi Ben Hadda
Journal:  Molecules       Date:  2016-02-17       Impact factor: 4.411

4.  Discovery of new imidazole derivatives containing the 2,4-dienone motif with broad-spectrum antifungal and antibacterial activity.

Authors:  Chunli Liu; Ce Shi; Fei Mao; Yong Xu; Jinyan Liu; Bing Wei; Jin Zhu; Mingjie Xiang; Jian Li
Journal:  Molecules       Date:  2014-09-29       Impact factor: 4.411

5.  4-[1-(Substituted aryl/alkyl carbonyl)-benzoimidazol-2-yl]-benzenesulfonic acids: synthesis, antimicrobial activity, QSAR studies, and antiviral evaluation.

Authors:  Snehlata Yadav; Pradeep Kumar; Erik De Clercq; Jan Balzarini; Christophe Pannecouque; Sharwan Kumar Dewan; Balasubramanian Narasimhan
Journal:  Eur J Med Chem       Date:  2010-10-07       Impact factor: 6.514

6.  Design, synthesis, biological assessment and in silico ADME prediction of new 2-(4-(methylsulfonyl) phenyl) benzimidazoles as selective cyclooxygenase-2 inhibitors.

Authors:  Mohamed A S Badawy; Eman K A Abdelall; El-Shaymaa El-Nahass; Khaled R A Abdellatif; Hamdy M Abdel-Rahman
Journal:  RSC Adv       Date:  2021-08-17       Impact factor: 4.036

7.  Synthesis and Evaluation of N-substituted Imidazole Derivatives for Antimicrobial Activity.

Authors:  Namita Gupta; D P Pathak
Journal:  Indian J Pharm Sci       Date:  2011-11       Impact factor: 0.975

8.  A benzimidazole derivative exhibiting antitumor activity blocks EGFR and HER2 activity and upregulates DR5 in breast cancer cells.

Authors:  B Chu; F Liu; L Li; C Ding; K Chen; Q Sun; Z Shen; Y Tan; C Tan; Y Jiang
Journal:  Cell Death Dis       Date:  2015-03-12       Impact factor: 8.469

9.  Synthesis, anti-bacterial and anti-protozoal activities of amidinobenzimidazole derivatives and their interactions with DNA and RNA.

Authors:  Andrea Bistrović; Luka Krstulović; Ivana Stolić; Domagoj Drenjančević; Jasminka Talapko; Martin C Taylor; John M Kelly; Miroslav Bajić; Silvana Raić-Malić
Journal:  J Enzyme Inhib Med Chem       Date:  2018-12       Impact factor: 5.051
  9 in total

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