Literature DB >> 18656988

Resin capsules: permeable containers for parallel/combinatorial solid-phase organic synthesis.

Isabelle Bouillon1, Miroslav Soural, Viktor Krchnák.   

Abstract

A resin capsule is a permeable container for resin beads designed for multiple/combinatorial solid-phase organic synthesis. Resin capsules consist of a high density polyethylene ring sealed with peek mesh on both sides. The cylindrical shape of resin capsules enabled space-saving packing into plastic columnlike reaction vessels commonly used for solid-phase organic synthesis. Resin capsules have been evaluated for their use in combinatorial synthesis, and a set of model compounds with excellent purity was prepared.

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Year:  2008        PMID: 18656988      PMCID: PMC2652863          DOI: 10.1021/cc800072g

Source DB:  PubMed          Journal:  J Comb Chem        ISSN: 1520-4766


  12 in total

1.  Solid-phase combinatorial synthesis using MicroKan reactors, Rf tagging, and directed sorting.

Authors:  X Y Xiao; R Li; H Zhuang; B Ewing; K Karunaratne; J Lillig; R Brown; K C Nicolaou
Journal:  Biotechnol Bioeng       Date:  2000       Impact factor: 4.530

2.  Revolutionizing Resin Handling for Combinatorial Synthesis.

Authors:  Butrus Atrash; Mark Bradley; Ryzard Kobylecki; Dan Cowell; John Reader
Journal:  Angew Chem Int Ed Engl       Date:  2001-03-02       Impact factor: 15.336

3.  Solid-phase gene assembly.

Authors:  K L Beattie; R F Fowler
Journal:  Nature       Date:  1991-08-08       Impact factor: 49.962

4.  General method for the rapid solid-phase synthesis of large numbers of peptides: specificity of antigen-antibody interaction at the level of individual amino acids.

Authors:  R A Houghten
Journal:  Proc Natl Acad Sci U S A       Date:  1985-08       Impact factor: 11.205

5.  The domino blocks: a simple solution for parallel solid-phase organic synthesis.

Authors:  V Krchnák; V Padĕra
Journal:  Bioorg Med Chem Lett       Date:  1998-11-17       Impact factor: 2.823

Review 6.  Gene synthesis technology: recent developments and future prospects.

Authors:  K L Beattie; N J Logsdon; R S Anderson; J M Espinosa-Lara; R Maldonado-Rodriguez; J D Frost
Journal:  Biotechnol Appl Biochem       Date:  1988-12       Impact factor: 2.431

7.  Solid-phase peptide synthesis under continuous-flow conditions.

Authors:  T J Lukas; M B Prystowsky; B W Erickson
Journal:  Proc Natl Acad Sci U S A       Date:  1981-05       Impact factor: 11.205

8.  Color-monitored solid-phase multiple peptide synthesis under low-pressure continuous-flow conditions.

Authors:  V Krchnák; J Vágner
Journal:  Pept Res       Date:  1990 Jul-Aug

9.  Grafted supports in solid-phase synthesis.

Authors:  F Rasoul; F Ercole; Y Pham; C T Bui; Z Wu; S N James; R W Trainor; G Wickham; N J Maeji
Journal:  Biopolymers       Date:  2000       Impact factor: 2.505

10.  A new general approach for the simultaneous chemical synthesis of large numbers of oligonucleotides: segmental solid supports.

Authors:  R Frank; W Heikens; G Heisterberg-Moutsis; H Blöcker
Journal:  Nucleic Acids Res       Date:  1983-07-11       Impact factor: 16.971

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