| Literature DB >> 18656548 |
Jean-Pierre Y Scheerlinck1, Deanne L V Greenwood.
Abstract
In a return to the early days of vaccine development during which effective vaccines were produced against viruses, virus-sized vaccine delivery systems have made a comeback. Using modern production technologies these nanoparticles have proved to be very effective at inducing cellular and humoral immune responses. Here, we review a number of vaccine delivery systems based on nanoparticles in the size range of typical viruses. Different strategies for generating these particles, ranging from recombinant virus-like particles to inert nanobeads via ISCOMs and nanoparticle-based DNA vaccine delivery systems, are discussed. In addition, possible mechanisms of immune induction are explored.Mesh:
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Year: 2008 PMID: 18656548 DOI: 10.1016/j.drudis.2008.06.016
Source DB: PubMed Journal: Drug Discov Today ISSN: 1359-6446 Impact factor: 7.851