OBJECTIVE: The aim of this prospective study was to evaluate the contribution of an initially shortened deceleration time of mitral inflow E velocity (E-wave DT) to predict survival in patients with left-ventricular (LV) systolic dysfunction in atrial fibrillation (AF) and in sinus rhythm (SR). BACKGROUND: To date, few data are available concerning the prognostic value of Doppler mitral profile in patients with AF, particularly in the presence of LV systolic dysfunction. METHODS: We studied the outcome of 140 consecutive patients with LV ejection fraction less than 40%. Complete history, physical examination and echocardiography were performed. RESULTS: Chronic AF was present in 40 (29%) patients. Over a mean follow-up of 25+/-11 months, 54 (39%) patients died, 18 in the AF group and 36 in the SR group. Ejection fraction was similar in the two groups (31% versus 32%, respectively). Survival curves indicated a significantly poorer prognosis for shortened E-wave DT less than 150 ms in the AF group and in the SR group (both p<or=0.01). Using multivariable Cox analysis, shortened E-wave DT was identified as an independent predictor of mortality in the AF group (exponential of coefficient: 0.97; chi-square: 5.82; p=0.01) and in the SR group (exponential of coefficient: 0.98; chi-square: 5.82; p=0.001). CONCLUSION: In patients with LV systolic dysfunction, a shortened deceleration time E-wave on Doppler examination appears to predict a similar poor prognosis in patients with AF as with SR.
OBJECTIVE: The aim of this prospective study was to evaluate the contribution of an initially shortened deceleration time of mitral inflow E velocity (E-wave DT) to predict survival in patients with left-ventricular (LV) systolic dysfunction in atrial fibrillation (AF) and in sinus rhythm (SR). BACKGROUND: To date, few data are available concerning the prognostic value of Doppler mitral profile in patients with AF, particularly in the presence of LV systolic dysfunction. METHODS: We studied the outcome of 140 consecutive patients with LV ejection fraction less than 40%. Complete history, physical examination and echocardiography were performed. RESULTS: Chronic AF was present in 40 (29%) patients. Over a mean follow-up of 25+/-11 months, 54 (39%) patients died, 18 in the AF group and 36 in the SR group. Ejection fraction was similar in the two groups (31% versus 32%, respectively). Survival curves indicated a significantly poorer prognosis for shortened E-wave DT less than 150 ms in the AF group and in the SR group (both p<or=0.01). Using multivariable Cox analysis, shortened E-wave DT was identified as an independent predictor of mortality in the AF group (exponential of coefficient: 0.97; chi-square: 5.82; p=0.01) and in the SR group (exponential of coefficient: 0.98; chi-square: 5.82; p=0.001). CONCLUSION: In patients with LV systolic dysfunction, a shortened deceleration time E-wave on Doppler examination appears to predict a similar poor prognosis in patients with AF as with SR.
Authors: Tal Hasin; Yan Topilsky; Walter K Kremers; Barry A Boilson; John A Schirger; Brooks S Edwards; Alfredo L Clavell; Richard J Rodeheffer; Robert P Frantz; Lyle Joyce; Richard Daly; John M Stulak; Sudhir S Kushwaha; Soon J Park; Naveen L Pereira Journal: Am J Cardiol Date: 2012-07-21 Impact factor: 2.778
Authors: Charlotte Andersson; Gunnar H Gislason; Peter Weeke; Jesper Kjaergaard; Christian Hassager; Dilek Akkan; Jacob E Møller; Lars Køber; Christian Torp-Pedersen Journal: BMC Cardiovasc Disord Date: 2012-04-25 Impact factor: 2.298