INTRODUCTION:Low-carbohydrate, high-protein diets are a current challenge in the nutritional treatment of obesity. OBJECTIVE: To compare the effect of a low-carbohydrate high-protein diet with a traditional hypocaloric diet on weight loss and mitochondrial oxidative metabolism. SUBJECTS AND METHODS: Nineteen obese men (age 36+/-6 years; body mass index 34+/-2 kg/m2) were randomized to follow one of the two diets-control diet (15% protein; 30% lipids; 55% carbohydrates) or high-protein diet (30% protein; 30% lipids; 40% carbohydrates)-over an 8-week period. Anthropometry, biochemical variables, resting energy expenditure and mitochondrial oxidation were measured at the start and at the end of the intervention. RESULTS: The high-protein diet produced a greater weight loss (-8.3+/-1.2% versus -5.5+/-2.5%, P = 0.012) than the control diet. Interestingly, an activation in the mitochondrial oxidation was found in the high-protein-fed group. This stimulation was positively correlated with the final resting energy expenditure and negatively associated with the final fat mass content. CONCLUSION:Low-carbohydrate high-protein diets could involve specific changes in mitochondrial oxidation that could be related to a higher weight loss.
RCT Entities:
INTRODUCTION: Low-carbohydrate, high-protein diets are a current challenge in the nutritional treatment of obesity. OBJECTIVE: To compare the effect of a low-carbohydrate high-protein diet with a traditional hypocaloric diet on weight loss and mitochondrial oxidative metabolism. SUBJECTS AND METHODS: Nineteen obesemen (age 36+/-6 years; body mass index 34+/-2 kg/m2) were randomized to follow one of the two diets-control diet (15% protein; 30% lipids; 55% carbohydrates) or high-protein diet (30% protein; 30% lipids; 40% carbohydrates)-over an 8-week period. Anthropometry, biochemical variables, resting energy expenditure and mitochondrial oxidation were measured at the start and at the end of the intervention. RESULTS: The high-protein diet produced a greater weight loss (-8.3+/-1.2% versus -5.5+/-2.5%, P = 0.012) than the control diet. Interestingly, an activation in the mitochondrial oxidation was found in the high-protein-fed group. This stimulation was positively correlated with the final resting energy expenditure and negatively associated with the final fat mass content. CONCLUSION: Low-carbohydrate high-protein diets could involve specific changes in mitochondrial oxidation that could be related to a higher weight loss.
Authors: P González-Muniesa; A Lopez-Pascual; J de Andrés; A Lasa; M P Portillo; F Arós; J Durán; C J Egea; J A Martinez Journal: J Physiol Biochem Date: 2015-04-26 Impact factor: 4.158
Authors: Rocio de la Iglesia; Patricia Lopez-Legarrea; Paloma Celada; Francisco J Sánchez-Muniz; J Alfredo Martinez; M Angeles Zulet Journal: Int J Mol Sci Date: 2013-03-27 Impact factor: 5.923