Ralph Rühl1, Achim Bub, Bernhard Watzl. 1. Apoptosis and Genomics Research Center, Hungarian Academy of Sciences, Laboratory of Nutritional Bioactivation and Bioanalysis, Department of Biochemistry and Molecular Biology, University of Debrecen, Debrecen, Hungary. rruehl@dote.hu
Abstract
OBJECTIVE: A human intervention trial was conducted to determine the effects of consumption of carotenoid-rich vegetables on levels of retinol (ROL) and the active vitamin A metabolite all-trans retinoic acid (ATRA). METHODS: The study was divided into four periods, each lasting 2 wk: weeks 1-2, a low carotenoid period; weeks 3-4, daily consumption of 330 mL of tomato juice; weeks 5-6, 330 mL of carrot juice daily; and weeks 7-8, 10 g of dried spinach powder daily. ROL and ATRA concentrations were measured after each 2-wk study period. RESULTS AND CONCLUSION: This study shows that consumption of carrot juice containing high concentrations of the pro-vitamin A carotenoid beta-carotene results in slightly, non-significantly increased plasma ROL concentrations and strong, significantly increased (almost double, from 1.2 +/- 0.3 to 2.0 +/- 0.31 ng/mL) plasma concentrations of ATRA, whereas consumption of tomato juice and spinach powder results in no significant alteration in concentrations of plasma ROL and ATRA.
RCT Entities:
OBJECTIVE: A human intervention trial was conducted to determine the effects of consumption of carotenoid-rich vegetables on levels of retinol (ROL) and the active vitamin A metabolite all-trans retinoic acid (ATRA). METHODS: The study was divided into four periods, each lasting 2 wk: weeks 1-2, a low carotenoid period; weeks 3-4, daily consumption of 330 mL of tomato juice; weeks 5-6, 330 mL of carrot juice daily; and weeks 7-8, 10 g of dried spinach powder daily. ROL and ATRA concentrations were measured after each 2-wk study period. RESULTS AND CONCLUSION: This study shows that consumption of carrot juice containing high concentrations of the pro-vitamin A carotenoidbeta-carotene results in slightly, non-significantly increased plasma ROL concentrations and strong, significantly increased (almost double, from 1.2 +/- 0.3 to 2.0 +/- 0.31 ng/mL) plasma concentrations of ATRA, whereas consumption of tomato juice and spinach powder results in no significant alteration in concentrations of plasma ROL and ATRA.
Authors: Ralph Rühl; Agnieszka Krzyżosiak; Anna Niewiadomska-Cimicka; Natacha Rochel; Lajos Szeles; Belén Vaz; Marta Wietrzych-Schindler; Susana Álvarez; Monika Szklenar; Laszlo Nagy; Angel R de Lera; Wojciech Krężel Journal: PLoS Genet Date: 2015-06-01 Impact factor: 5.917
Authors: Victor W Ho; Elyse Hofs; Ingrid Elisia; Vivian Lam; Brian E Hsu; June Lai; Beryl Luk; Ismael Samudio; Gerald Krystal Journal: PLoS One Date: 2016-12-15 Impact factor: 3.240
Authors: Torsten Bohn; Charles Desmarchelier; Lars O Dragsted; Charlotte S Nielsen; Wilhelm Stahl; Ralph Rühl; Jaap Keijer; Patrick Borel Journal: Mol Nutr Food Res Date: 2017-02-27 Impact factor: 5.914
Authors: Gamze Aydemir; Marta Domínguez; Angel R de Lera; Johanna Mihaly; Dániel Törőcsik; Ralph Rühl Journal: Nutrients Date: 2019-09-04 Impact factor: 5.717
Authors: Elske M Brouwer-Brolsma; Beate Brandl; Marion E C Buso; Thomas Skurk; Claudine Manach Journal: Genes Nutr Date: 2020-04-09 Impact factor: 5.523
Authors: Renata Lucas; Johanna Mihály; Gordon M Lowe; Daniel L Graham; Monika Szklenar; Andrea Szegedi; Daniel Töröcsik; Ralph Rühl Journal: Nutrients Date: 2018-10-01 Impact factor: 5.717